The adaptation of CRISPR/SpCas9 technology to mammalian cell lines is transforming the
study of human functional genomics. Pooled libraries of CRISPR guide RNAs (gRNAs) …

A new derivation is presented for the bounds on the size of a multilayer neural network to
exactly implement an arbitrary training set; namely the training set can be implemented with …

HECT-family E3 ligases ubiquitinate protein substrates to control virtually every eukaryotic
process and are misregulated in numerous diseases. Nonetheless, understanding of HECT …

Regulation of translation during human development is poorly understood, and its
dysregulation is associated with Rett syndrome (RTT). To discover shifts in mRNA ribosomal …

Skp1–Cul1–F-box (SCF) E3 ligases play key roles in multiple cellular processes through
ubiquitination and subsequent degradation of substrate proteins. Although Skp1 and Cul1 are …

Post-translational modification of the p53 signaling pathway plays an important role in cell
cycle progression and stress-induced apoptosis. Indeed, a large body of work has shown that …

The systematic storage in neural networks of prior information to be used in the design of
various control subsystems is investigated. Assuming that the prior information is available in a …

Smurf1 and Smurf2 are two closely related member of the HECT (homologous to E6AP carboxy
terminus) E3 ubiquitin ligase family and play important roles in the regulation of various …

A type of neural network, the multilayer perceptron, is used to classify numeric data and assign
appropriate symbols to various classes. This numeric-to-symbolic conversion results in a …

In rule-based artificial intelligence (AI) planning, expert, and learning systems, it is often the
case that the left-hand-sides of the rules must be repeatedly compared to the contents of …