μManager is an open-source, cross-platform desktop application, to control a wide variety of
motorized microscopes, scientific cameras, stages, illuminators, and other microscope …

Crawling locomotion of eukaryotic cells is achieved by a process dependent on the actin
cytoskeleton 1 : protrusion of the leading edge requires assembly of a network of actin filaments …

To the Editor—Cutting-edge innovations in biological microscopy are increasingly blurring
the line between data acquisition and data analysis. Computational microscopy and machine-…

Hydrogen bonds play major roles in biological structure and function. Nonetheless,
hydrogen-bonded protons are not typically observed by X-ray crystallography, and most structural …

… In an attempt to appropriately simulate the trajectories of the majority of keratocytes with
persistent turning and high A(u), we next attempted simulating stochastic variations in the time …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …

Networks of polymerizing actin filaments can propel intracellular pathogens and drive movement
of artificial particles in reconstituted systems. While biochemical mechanisms activating …

Fluorescence lifetime imaging microscopy (FLIM) provides valuable quantitative insights into
fluorophores’ chemical microenvironment. Due to long computation times and the lack of …

KAGRA is a gravitational-wave (GW) detector constructed in Japan with two unique key
features: It was constructed underground, and the test-mass mirrors are cooled to cryogenic …

A critical issue for clinical utilization of human ES cells (hESCs) is whether they can generate
terminally mature progenies with normal function. We recently developed a method for …