The dopamine system is involved in motivation, reward and learning, and dysfunction in this
system has been implicated in several disorders, including Parkinson's disease (PD) and …

Disrupted salience processing is proposed as central in linking dysregulated dopamine function
with psychotic symptoms. Several strands of evidence are now converging in support of …

… Mark A Ungless … Mark A Ungless … Copyright: © 2006 Lüscher and Ungless. This is
an open-access article distributed under the terms of the Creative Commons Attribution …

How do drugs of abuse modify neural circuitry and thereby lead to addictive behaviour? As
for many forms of experience-dependent plasticity, modifications in glutamatergic synaptic …

Midbrain dopamine neurons play central roles in reward processing. It is widely assumed
that all dopamine neurons encode the same information. Some evidence, however, suggests …

Dopamine neurons play a key role in reward-related behaviors. Reward coding theories
predict that dopamine neurons will be inhibited by or will not respond to aversive stimuli. …

Midbrain dopamine neurons in the ventral tegmental area, substantia nigra and retrorubral
field play key roles in reward processing, learning and memory, and movement. Within these …

The motivation to seek social contact may arise from either positive or negative emotional
states, as social interaction can be rewarding and social isolation can be aversive. While …

Stress increases addictive behaviors and is a common cause of relapse. Corticotropin-releasing
factor (CRF) plays a key role in the modulation of drug taking by stress. However, the …

Stress plays a key role in modulating the development and expression of addictive behavior,
and is a major cause of relapse following periods of abstinence. In this review we focus our …