The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
The mammalian target of rapamycin (mTOR) protein kinase is a master growth promoter
that nucleates two complexes, mTORC1 and mTORC2. Despite the diverse processes …
that nucleates two complexes, mTORC1 and mTORC2. Despite the diverse processes …
[HTML][HTML] The structural basis for 14-3-3: phosphopeptide binding specificity
MB Yaffe, K Rittinger, S Volinia, PR Caron, A Aitken… - Cell, 1997 - cell.com
The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing
proteins. Using phosphoserine-oriented peptide libraries to probe all mammalian …
proteins. Using phosphoserine-oriented peptide libraries to probe all mammalian …
TCP1 complex is a molecular chaperone in tubulin biogenesis
MB Yaffe, GW Farr, D Miklos, AL Horwich, ML Sternlicht… - Nature, 1992 - nature.com
A ROLE in folding of newly translated proteins in the cytosol of eukaryotes has been proposed
for t-complex polypeptide-1 (TCP1), although its molecular targets have not yet been …
for t-complex polypeptide-1 (TCP1), although its molecular targets have not yet been …
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport
…, JA DeCaprio, ME Greenberg, MB Yaffe - The Journal of cell …, 2002 - rupress.org
… Yaffe; 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic
transport . J Cell Biol 4 March 2002; 156 (5): 817–828. doi: https://doi.org/10.1083/jcb.200112059 …
transport . J Cell Biol 4 March 2002; 156 (5): 817–828. doi: https://doi.org/10.1083/jcb.200112059 …
[HTML][HTML] How do 14-3-3 proteins work?–Gatekeeper phosphorylation and the molecular anvil hypothesis
MB Yaffe - FEBS letters, 2002 - Elsevier
14-3-3 proteins were the first signaling molecules to be identified as discrete phosphoserine/threonine
binding modules. This family of proteins, which includes seven isotypes in human …
binding modules. This family of proteins, which includes seven isotypes in human …
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
HC Reinhardt, MB Yaffe - Current opinion in cell biology, 2009 - Elsevier
In response to DNA damage eukaryotic cells activate cell cycle checkpoints—complex
kinase signaling networks that prevent further progression through the cell cycle. Parallel to …
kinase signaling networks that prevent further progression through the cell cycle. Parallel to …
MAP kinase pathways activated by stress: the p38 MAPK pathway
T Obata, GE Brown, MB Yaffe - Critical care medicine, 2000 - journals.lww.com
A stress-activated serine/threonine protein kinase, p38 mitogen-activated protein kinase (p38
MAPK), belongs to the MAP kinase superfamily. Diverse extracellular stimuli, including …
MAPK), belongs to the MAP kinase superfamily. Diverse extracellular stimuli, including …
[HTML][HTML] Systematic discovery of in vivo phosphorylation networks
Protein kinases control cellular decision processes by phosphorylating specific substrates.
Thousands of in vivo phosphorylation sites have been identified, mostly by proteome-wide …
Thousands of in vivo phosphorylation sites have been identified, mostly by proteome-wide …
A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis
Signal transduction pathways control cellular responses to stimuli, but it is unclear how
molecular information is processed as a network. We constructed a systems model of 7980 …
molecular information is processed as a network. We constructed a systems model of 7980 …
Linear motif atlas for phosphorylation-dependent signaling
Systematic and quantitative analysis of protein phosphorylation is revealing dynamic
regulatory networks underlying cellular responses to environmental cues. However, matching …
regulatory networks underlying cellular responses to environmental cues. However, matching …