Vertebrate development begins with precise molecular, cellular, and morphogenetic
controls to establish the basic body plan of the embryo. In zebrafish, these tightly regulated …

The earliest stages of embryonic development in all animals examined rely on maternal
gene products that are generated during oogenesis and supplied to the egg. The period of …

TGF-β family ligands function in inducing and patterning many tissues of the early vertebrate
embryonic body plan. Nodal signaling is essential for the specification of mesendodermal …

In a large-scale screen, we isolated mutants displaying a specific visible phenotype in
embryos or early larvae of the zebrafish, Danio rerio. Males were mutagenized with …

Background: In Drosophila melanogaster and Caenorhabditis elegans, the elucidation of
developmental mechanisms has relied primarily on the systematic induction and isolation of …

Zebrafish embryos and larvae have stage-specific patterns of motility or locomotion. Two
embryonic structures accomplish this behavior: the central nervous system (CNS) and skeletal …

Somitogenesis is the basis of segmentation of the mesoderm in the trunk and tail of
vertebrate embryos. Two groups of mutants with defects in this patterning process have been …

In a screen for early developmental mutants of the zebrafish, we have identified mutations
specifically affecting the internal organs. We identified 53 mutations affecting the …

Neural crest development involves cell-fate specification, proliferation, patterned cell
migration, survival and differentiation. Zebrafish neural crest derivatives include three distinct …

We identified 6 genes that are essential for specifying ventral regions of the early zebrafish
embryo. Mutations in these genes cause an expansion of structures normally derived from …