User profiles for M. C. O’Donovan
Michael O'DonovanCardiff University Verified email at cardiff.ac.uk Cited by 132623 |
The genetics of schizophrenia and bipolar disorder: dissecting psychosis
Much work has been done to identify susceptibility genes in schizophrenia and bipolar
disorder. Several well established linkages have emerged in schizophrenia. Strongly supported …
disorder. Several well established linkages have emerged in schizophrenia. Strongly supported …
Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology
It has been conventional for psychiatric research, including the search for predisposing
genes, to proceed under the assumption that schizophrenia and bipolar disorder are separate …
genes, to proceed under the assumption that schizophrenia and bipolar disorder are separate …
Psychiatric genomics: an update and an agenda
…, JW Smoller, MC O'Donovan… - American Journal of …, 2018 - Am Psychiatric Assoc
The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of
psychiatry. This global effort is dedicated to rapid progress and open science, and in the past …
psychiatry. This global effort is dedicated to rapid progress and open science, and in the past …
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
…, P Lichtenstein, A McQuillin, WJ Muir, MC O'Donovan… - Nature, 2009 - nature.com
Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80% 1 , 2 . …
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80% 1 , 2 . …
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
…, D Church, L Doucette-Stamm, MC O'Donovan… - Cell, 1993 - cell.com
The Huntington's disease (HD) gene has been mapped in 4p16.3 but has eluded identification.
We have used haplotype analysis of linkage disequilibrium to spotlight a small segment …
We have used haplotype analysis of linkage disequilibrium to spotlight a small segment …
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
…, PV Jonsson, O Combarros, MC O'Donovan… - Nature …, 2013 - nature.com
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …
studies; however, a large portion of the genetic risk for this disease remains unexplained. …
De novo mutations in schizophrenia implicate synaptic networks
Inherited alleles account for most of the genetic risk for schizophrenia. However, new (de
novo) mutations, in the form of large chromosomal copy number changes, occur in a small …
novo) mutations, in the form of large chromosomal copy number changes, occur in a small …
[PDF][PDF] Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
…, J Lönnqvist, L Peltonen, MC O'Donovan… - The American Journal of …, 2003 - cell.com
Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to
siblings of probands. Replication has been inconsistent for reports of significant genetic …
siblings of probands. Replication has been inconsistent for reports of significant genetic …
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …