The finding that sequence-specific gene silencing occurs in response to the presence of
double-stranded RNAs has had an enormous impact on biology, uncovering an unsuspected …

Small RNAs of 20–30 nucleotides can target both chromatin and transcripts, and thereby keep
both the genome and the transcriptome under extensive surveillance. Recent progress in …

PIWI-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs that form the
piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The …

… Kinouchi for assistance with fly husbandry and dissection; and members of the Siomi laboratory
for discussions and comments on the manuscript. Supported by the Ministry of Education…

… Nakamura, and members of the Siomi laboratory for discussions and comments on the
manuscript. KO and AI are predoctoral fellows of the 21 st century COE Program from the Ministry …

… motif, the KH domain, that we have recently described in the hnRNP K protein (Siomi et al.,
1993… extends over -40 amino acids, was originally found in the hnRNP K protein (Siomi et al., …

… We thank members of the Siomi laboratory for discussions and comments on the
manuscript. We also thank S. Hayashi for anti-DE-cadherin, and T. … Siomi MC … Siomi MC …

… Haruhiko Siomi… Siomi and MC Siomi, in prep.; Fig.1B). … Nakahori and members of the
Siomi laboratory for discussions and A. Azuma and Y. Kawamura for technical assistance. …

… The authors would like to thank members of the Siomi laboratory for discussions and three
anonymous referees for their useful comments. We apologize to colleagues whose relevant …

PIWI-interacting RNAs (piRNAs) are a class of small RNAs that are 24–31 nucleotides in
length. They associate with PIWI proteins, which constitute a germline-specific subclade of the …