Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

Strong signatures of positive selection at newly arising genetic variants are well documented
in humans 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , but this form of selection may not be widespread in …

10.7554/eLife.39702.001 Genetic predictions of height differ among human populations
and these differences have been interpreted as evidence of polygenic adaptation. These …

Human populations have undergone major changes in population size in the past 100,000
years, including recent rapid growth. How these demographic events have affected the …

Chronic kidney disease (CKD) is a common complex condition associated with high
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …

Height is a model polygenic trait that is highly heritable. Genome-wide association studies
have identified hundreds of single-nucleotide polymorphisms associated with stature, but the …

Proteins present in the seminal fluid of Drosophila melanogaster (accessory gland proteins
Acps) contribute to female postmating behavioral changes, sperm storage, sperm competition…

Genetic predictions of height differ significantly among human populations and these
differences are too large to be explained by random genetic drift. This observation has been …

Genome-wide association studies (GWAS) have now been conducted for hundreds of
phenotypes of relevance to human health. Many such GWAS involve multiple closely-related …

In order to gain further insight into the processes underlying rapid reproductive protein
evolution, we have conducted a population genetic survey of 44 reproductive tract–expressed …