Metabolic reprogramming is a key feature of many cancers, but how and when it contributes
to tumorigenesis remains unclear. Here we demonstrate that metabolic reprogramming …

Squamous cell carcinomas are triggered by marked elevation of RAS–MAPK signalling and
progression from benign papilloma to invasive malignancy 1 , 2 , 3 – 4 . At tumour–stromal …

Lineage plasticity—a state of dual fate expression—is required to release stem cells from
their niche constraints and redirect them to tissue compartments where they are most needed. …

10.7554/eLife.46566.001 Neural progenitors undergo temporal patterning to generate
diverse neurons in a chronological order. This process is well-studied in the developing …

During central nervous system development, spatiotemporal gene expression programs
mediate specific lineage decisions to generate neuronal and glial cell types from neural stem …

Hepatocellular carcinoma (HCC) is the third most common cause of death from cancer
worldwide due to the challenges in both its diagnosis and treatment. According to recent studies, …

Feedforward loops (FFLs) are relatively simple network motifs, made of three interacting
genes, that have been found in a large number in E. coli and S. cerevisiae. More recently, they …

Drosophila melanogaster neural stem cells (neuroblasts [NBs]) divide asymmetrically by
differentially segregating protein determinants into their daughter cells. Although the machinery …

Known for nearly a century but through mechanisms that remain elusive, cells retain a memory
of inflammation that equips them to react quickly and broadly to diverse secondary stimuli…

Cancer stem cells (CSCs) are a small population of cells in human malignancies that
resemble the biology of human pluripotent stem cells. CSCs are closely related to the critical …