Exosomes play a role in cell-to-cell signaling and serve as possible biomarkers. Isolating
exosomes with reliable quality and substantial concentration is a major challenge. Our purpose …

Both exfoliation glaucoma (XFG) and primary open-angle glaucoma (POAG) have been
linked to decreased conventional outflow of aqueous humor (AH). To better understand the …

Purpose: Keratoconus (KC) is the most common corneal ectasia. We aimed to determine the
differential expression of coding and long noncoding RNAs (lncRNAs) in human corneas …

Keratoconus (KC) is the most common corneal ectatic disorder affecting >300,000 people in
the US. KC normally has its onset in adolescence, progressively worsening through the third …

Purpose: Intraocular pressure (IOP), the primary risk factor for primary open-angle glaucoma,
is determined by resistance to aqueous outflow through the trabecular meshwork (TM). IOP …

Current treatments of facial nerve injury result in poor functional outcomes due to slow and
inefficient axon regeneration and aberrant reinnervation. To address these clinical challenges…

An effective strategy for sustained neurotrophic factor (NTF) delivery to sites of peripheral
nerve injury (PNI) would accelerate healing and enhance functional recovery, addressing the …

Reduced reproduction increases storage and extends lifespan in several animal species.
The disposable soma hypothesis suggests this life extension occurs by shifting allocation of …

Dietary restriction (DR) and reduced reproduction each extend life span in many species.
Females undergoing DR typically experience a reduction in their fecundity, which raises the …

Peripheral nerves have an inherent capacity for regeneration, but these Schwann cell-mediated
mechanisms are insufficient for severe injuries. With current clinical treatments, slow …