In the mammalian pancreas, endocrine cells undergo lineage allocation upon emergence
from a bipotent duct/endocrine progenitor pool, which resides in the “trunk epithelium.” Major …

… Quantification of delaminating Neurog3 RG1-HI cells showed that 100% involved apically
connected lumenal tethers (CVE Wright, ME Bechard, and E Bankaitis, in prep.; data not shown…

Apicobasal polarity is known to affect epithelial morphogenesis and cell differentiation, but it
remains unknown how these processes are mechanistically orchestrated. We find that ligand…

Although metastasis is the most common cause of cancer deaths, metastasis-intrinsic
dependencies remain largely uncharacterized. We previously reported that metastatic pancreatic …

During mouse pancreas organogenesis, endocrine cells are born from progenitors residing
in an epithelial plexus niche. After a period in a lineage-primed Neurog3 LO state, …

Pancreatic ductal adenocarcinoma (PDAC) adopts several unique metabolic strategies to
support primary tumor growth. Whether additional metabolic strategies are adopted to support …

Patient-derived tumor organoid cultures are an essential and innovative methodology for
translational research. However, current techniques to establish these cultures are …

Metastatic outgrowth is supported by metabolic adaptations that may differ from the primary
tumor of origin. However, it is unknown if such adaptations are therapeutically actionable. …

… Bechard 2 , Mason A. Lee 2 3 , Oliver G. McDonald 2 4 5 , Ethan Lee 1 3 4 , Vivian L. …
Bechard, A. Vilgelm, N. Baregamian, O. …

Tetrahydromethanopterin (H 4 MPT) is a tetrahydrofolate analog originally discovered in
methanogenic archaea, but later found in other archaea and bacteria. The extent to which …