Parkinson’s disease, the most common age-related movement disorder, is a progressive
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are Lewy …

In normal airways, hyaluronan (HA) matrices are primarily located within the airway submucosa,
pulmonary vasculature walls, and, to a lesser extent, the alveoli. Following pulmonary …

10.7554/eLife.36402.001 Parkinson’s disease is a progressive neuropathological disorder
that belongs to the class of synucleinopathies, in which the protein alpha-synuclein is found …

Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological
diseases including Parkinson’s disease (PD). Previously, we reported the structure of alpha-…

The cell and its glycosaminoglycan-rich pericellular matrix (PCM) comprise a functional unit.
Because modification of PCM influences cell behavior, we investigated molecular …

A balanced turnover of dermal fibroblasts is crucial for structural integrity and normal function
of the skin. During recovery from environmental injury (such as UV exposure and physical …

Twenty-four families who had participated in a Home Care Program for children terminally ill
with cancer and 13 families of similar children who had died in the hospital completed …

Asthma is a chronic inflammatory disease of the airways characterized by airway remodeling,
which includes changes in the extracellular matrix (ECM). However the role of the ECM in …

Tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6) binds to hyaluronan and can
reorganize/stabilize its structure, also enhancing the binding of this glycosaminoglycan to its cell …

Purpose Development of a method to assess the drug/polymer miscibility and stability of
solid dispersions using a melt-based mixing method. Methods Amorphous fractured films are …