Despite renin-angiotensin-aldosterone system blockade, which retards progression of CKD
by reducing proteinuria, many patients with CKD have residual proteinuria, an independent …

Vitamin D is typically viewed as a key player in the regulation of calcium and phosphate levels
and the control of bone metabolism; however, growing evidence suggests that vitamin D …

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits (systolic, diastolic …

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

… MHdB. is consultant for and has received research grants and honoraria (to employer)
from Amgen, AstraZeneca, Bayer and Vifor Fresenius Medical Care Renal Pharma. LV is …

Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with
high arterial blood pressure and hypertension risk, but whether this association is causal is …

… De Borst is supported by personal development grants from the Dutch Kidney foundation
(KJPB.08.07) and the University Medical Center Groningen (Mandema stipend), and by the …

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly
understood mechanisms. We performed a trans-ancestry genome-wide association study …

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial
genetic contribution. Genetic variation influencing blood pressure has the potential to …

HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at
which common variants with minor allele frequency >5% are associated with kidney function. …