Human exposure to nanomaterials and nanoparticles is increasing rapidly, but their effects
on human health are still largely unknown. Epigenetic modifications are attracting ever more …

The poor correlation of mutational landscapes with phenotypes limits our understanding of
the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we …

Pluripotent stem cells (PSCs) may provide a potential source of haematopoietic stem/progenitor
cells (HSPCs) for transplantation; however, unknown molecular barriers prevent the self-…

Reversible ubiquitination orchestrated by the opposition of ubiquitin ligases and
deubiquitinating enzymes mediates endocytic trafficking of cell surface receptors for lysosomal …

Pluripotent stem cells (PSCs) transition between cell states in vitro, reflecting developmental
changes in the early embryo. PSCs can be stabilized in the naive state by blocking …

Reversible ubiquitination is essential for the endocytic sorting and down-regulation of G
protein-coupled receptors, such as the chemokine receptor CXCR4. The deubiquitinating …

In man, neurotoxicity associated to ifosfamide treatment can be reversed by intravenous
thiamine administration. Trying to explain this clinical finding, we decided to study possible …

Humans are increasingly exposed to nanoparticles and, although many of their physiological
effects have been described, the molecular mechanisms underlying them are still largely …

BACKGROUND Recently the α 1 adrenergic receptor antagonist terazosin was shown to
activate PGK1, a possible target for the mitochondrial deficits in Parkinson disease related to its …

Ten-eleven translocation (TET) enzymes are frequently deregulated in cancer, but the
underlying molecular mechanisms are still poorly understood. Here we report that TET2 shows …