[HTML][HTML] Influenza virus activation of the interferon system
MJ Killip, E Fodor, RE Randall - Virus research, 2015 - Elsevier
The host interferon (IFN) response represents one of the first barriers that influenza viruses
must surmount in order to establish an infection. Many advances have been made in recent …
must surmount in order to establish an infection. Many advances have been made in recent …
[HTML][HTML] Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort …
…, AM Bown, EJ Truelove, MJ Killip… - The Lancet Infectious …, 2023 - thelancet.com
Background The scale of the 2022 global mpox (formerly known as monkeypox) outbreak
has been unprecedented. In less than 6 months, non-endemic countries have reported more …
has been unprecedented. In less than 6 months, non-endemic countries have reported more …
Analysis of inactivation of SARS-CoV-2 by specimen transport media, nucleic acid extraction reagents, detergents, and fixatives
…, CB Bruce, ADG Roberts, MJ Killip - Journal of clinical …, 2020 - Am Soc Microbiol
The COVID-19 pandemic has necessitated a multifaceted rapid response by the scientific
community, bringing researchers, health officials, and industry together to address the ongoing …
community, bringing researchers, health officials, and industry together to address the ongoing …
The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm
H Xiao, MJ Killip, P Staeheli, RE Randall… - Journal of …, 2013 - Am Soc Microbiol
The induction of an interferon-induced antiviral state is a powerful cellular response against
viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits …
viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits …
Mini viral RNAs act as innate immune agonists during influenza virus infection
…, JY Siegers, MJ Killip, H French, MJ Oliva-Martín… - Nature …, 2018 - nature.com
The molecular processes that determine the outcome of influenza virus infection in humans
are multifactorial and involve a complex interplay between host, viral and bacterial factors 1 . …
are multifactorial and involve a complex interplay between host, viral and bacterial factors 1 . …
Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein
…, BL Precious, A Gray, MJ Killip… - Proceedings of the …, 2010 - National Acad Sciences
Seasonal epidemics and periodic worldwide pandemics caused by influenza A viruses are
of continuous concern. The viral nonstructural (NS1) protein is a multifunctional virulence …
of continuous concern. The viral nonstructural (NS1) protein is a multifunctional virulence …
[HTML][HTML] Effective in vitro inactivation of SARS-CoV-2 by commercially available mouthwashes
…, PJ Nixon, DW Seymour, MJ Killip - Journal of General …, 2021 - microbiologyresearch.org
Infectious SARS-CoV-2 can be recovered from the oral cavities and saliva of COVID-19 patients
with potential implications for disease transmission. Reducing viral load in patient saliva …
with potential implications for disease transmission. Reducing viral load in patient saliva …
[HTML][HTML] Heterocellular induction of interferon by negative-sense RNA viruses
S Chen, JAL Short, DF Young, MJ Killip, M Schneider… - Virology, 2010 - Elsevier
The infection of cells by RNA viruses is associated with the recognition of virus PAMPs (pathogen-associated
molecular patterns) and the production of type I interferon (IFN). To counter …
molecular patterns) and the production of type I interferon (IFN). To counter …
Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction
MJ Killip, DF Young, D Gatherer, CS Ross… - Journal of …, 2013 - Am Soc Microbiol
Preparations of parainfluenza virus 5 (PIV5) that are potent activators of the interferon (IFN)
induction cascade were generated by high-multiplicity passage in order to accumulate …
induction cascade were generated by high-multiplicity passage in order to accumulate …
[HTML][HTML] Loss of function of the influenza A virus NS1 protein promotes apoptosis but this is not due to a failure to activate phosphatidylinositol 3-kinase (PI3K)
D Jackson, MJ Killip, CS Galloway, RJ Russell… - Virology, 2010 - Elsevier
A panel of influenza A viruses encoding mutant NS1 proteins was created in which a
number of NS1 functions, including interactions with dsRNA, PI3K, CPSF30 and PKR, were …
number of NS1 functions, including interactions with dsRNA, PI3K, CPSF30 and PKR, were …