What's in a spliceosome? More than we ever imagined, according to recent reports employing
proteomics techniques to analyze this multi-megadalton machine. As of 1999, around 100 …

Recent work indicates that the posttranscriptional control of eukaryotic gene expression is
much more elaborate and extensive than previously thought, with essentially every step of …

The pathway from gene activation in the nucleus to mRNA translation and decay at specific
locations in the cytoplasm is both streamlined and highly interconnected. This review …

Spike (S) proteins of coronaviruses, including the coronavirus that causes severe acute
respiratory syndrome (SARS), associate with cellular receptors to mediate infection of their target …

PURPOSE Most patients with advanced pancreas cancer experience pain and must limit
their daily activities because of tumor-related symptoms. To date, no treatment has had a …

Purpose Patients with advanced pancreatic cancer have a poor prognosis and there have
been no improvements in survival since the introduction of gemcitabine in 1996. Pancreatic …

Background Treatment with cetuximab, a monoclonal antibody directed against the epidermal
growth factor receptor, improves overall and progression-free survival and preserves the …

Background The combination of fluorouracil and leucovorin has until recently been standard
therapy for metastatic colorectal cancer. Irinotecan prolongs survival in patients with …

PURPOSE: Gemcitabine plus cisplatin (GC) and methotrexate, vinblastine, doxorubicin, and
cisplatin (MVAC) were compared in patients with locally advanced or metastatic transitional-…

Background Colon cancers with high-frequency microsatellite instability have clinical and
pathological features that distinguish them from microsatellite-stable tumors. We investigated …