User profiles for M. J. O'Neill

Michael O'Neill

- Verified email at lilly.com - Cited by 10791

Michael J. O'Neill

- Verified email at uconn.edu - Cited by 3531

[HTML][HTML] Accurate whole human genome sequencing using reversible terminator chemistry

…, T Newington, Z Ning, B Ling Ng, SM Novo, MJ O'Neill… - nature, 2008 - nature.com
DNA sequence information underpins genetic research, enabling discoveries of important
biological or medical benefit. Sequencing projects have traditionally used long (400–800 …

A Differential Scanning Calorimeter for Quantitative Differential Thermal Analysis.

ES Watson, MJ O'neill, J Justin, N Brenner - Analytical Chemistry, 1964 - ACS Publications
A Differential Scanning Calorimeter for Quantitative Differential Thermal Analysis. rect as far
as it goes. The barrier theory, by contrast, is less concrete and has been responsiblefor a …

Undermethylation associated with retroelement activation and chromosome remodelling in an interspecific mammalian hybrid

RJW O'Neill, MJ O'Neill, JAM Graves - Nature, 1998 - nature.com
Genetic models 1 , 2 predict that genomic rearrangement in hybrids can facilitate reproductive
isolation and the formation of new species by preventing gene flow between the parent …

Measurement of Specific Heat Functions by Differential Scanning Calorimetry.

MJ O'neill - Analytical chemistry, 1966 - ACS Publications
When a sample material is sub-jected to a linear temperature program, the heat flow rate into
the sample is proportional to its instantaneous specific heat. By recording this heat flow rate …

[HTML][HTML] A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not …

…, I Lavenir, M Goedert, ML Hutton, MJ O'Neill - Acta …, 2014 - Springer
Intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of
Alzheimer’s disease, progressive supranuclear palsy, Pick’s disease and other sporadic …

Impaired glymphatic function and clearance of tau in an Alzheimer's disease model

…, TK Murray, OP Ottersen, EA Nagelhus, MJ O'Neill… - Brain, 2020 - academic.oup.com
The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with interstitial
fluid (ISF), may provide a clearance pathway for protein species such as amyloid-β and tau…

The Analysis of a Temperature-Controlled Scanning Calorimeter.

MJ O'neill - Analytical chemistry, 1964 - ACS Publications
The features of various types of scanning calorimeters are described and compared. It is
shown that pro-portional temperature control of a sample-holding surface, with simul-taneous …

Effects of signage and floor plan configuration on wayfinding accuracy

MJ O'Neill - Environment and behavior, 1991 - journals.sagepub.com
Signage is commonly employed to enhance wayfinding efficiency, especially in buildings
with complex floor plan configurations. This study examines the influence of floor plan …

A model for predicting surgical outcome in patients with advanced ovarian carcinoma using computed tomography

…, NC Lambrou, EK Fishman, MJ O'Neill… - … Journal of the …, 2000 - Wiley Online Library
BACKGROUND A reliable model for predicting the outcome of primary cytoreductive
surgery may be a useful tool in the clinical management of patients with advanced epithelial …

[HTML][HTML] Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression

…, N Buckner, J Hanmer, P Davies, MJ O'Neill… - Journal of Biological …, 2011 - ASBMB
The microtubule-associated protein Tau plays a critical role in the pathogenesis of Alzheimer
disease and several related disorders (tauopathies). In the disease Tau aggregates and …