User profiles for M. K. Aghi
Manish AghiVerified email at neurosurg.ucsf.edu Cited by 30273 |
Application of novel response/progression measures for surgically delivered therapies for gliomas: Response Assessment in Neuro-Oncology (RANO) Working Group
BACKGROUND: The Response Assessment in Neuro-Oncology (RANO) Working Group is
an international, multidisciplinary effort to develop new standardized response criteria for …
an international, multidisciplinary effort to develop new standardized response criteria for …
Biology of angiogenesis and invasion in glioma
MC Tate, MK Aghi - Neurotherapeutics, 2009 - Elsevier
Treatment of adult brain tumors, in particular glioblastoma, remains a significant clinical
challenge, despite modest advances in surgical technique, radiation, and chemotherapeutics. …
challenge, despite modest advances in surgical technique, radiation, and chemotherapeutics. …
Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy
Autophagy is a lysosomal degradation pathway that can sequester cytosolic material, including
organelles, nonspecifically in a process called nonselective macroautophagy, or target …
organelles, nonspecifically in a process called nonselective macroautophagy, or target …
[PDF][PDF] VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex
…, JP Chang, CA Parachoniak, MM Pandika, MK Aghi… - Cancer cell, 2012 - cell.com
Inhibition of VEGF signaling leads to a proinvasive phenotype in mouse models of glioblastoma
multiforme (GBM) and in a subset of GBM patients treated with bevacizumab. Here, we …
multiforme (GBM) and in a subset of GBM patients treated with bevacizumab. Here, we …
Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma
Antiangiogenic therapy leads to devascularization that limits tumor growth. However, the
benefits of angiogenesis inhibitors are typically transient and resistance often develops. In this …
benefits of angiogenesis inhibitors are typically transient and resistance often develops. In this …
Impact of extent of resection for recurrent glioblastoma on overall survival
Object Extent of resection (EOR) has been shown to be an important prognostic factor for
survival in patients undergoing initial resection of glioblastoma (GBM), but the significance of …
survival in patients undergoing initial resection of glioblastoma (GBM), but the significance of …
Long-term recurrence rates of atypical meningiomas after gross total resection with or without postoperative adjuvant radiation
… Aghi et al. undertook a retrospective review of 108 atypical meningiomas after gross total
resection over an 11-year period at the Massachusetts General Hospital. This is an important …
resection over an 11-year period at the Massachusetts General Hospital. This is an important …
The phenotypes of proliferating glioblastoma cells reside on a single axis of variation
Tumor-propagating cells can be derived from mesenchymal and proneural glioblastomas.
However, a stem cell of the classic subtype has yet to be demonstrated. We show that classic-…
However, a stem cell of the classic subtype has yet to be demonstrated. We show that classic-…
Heat-shock protein peptide complex–96 vaccination for recurrent glioblastoma: a phase II, single-arm trial
Background Outcomes for patients with recurrent glioblastoma multiforme (GBM) are poor
and may be improved by immunotherapy. We investigated the safety and efficacy of an …
and may be improved by immunotherapy. We investigated the safety and efficacy of an …
Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance
…, MM Chaumeil, SM Ronen, G Bergers, MK Aghi - Clinical Cancer …, 2013 - AACR
… This work was supported by funding to MK Aghi's laboratory from the American Brain
Tumor Association, the James S. McDonnell Foundation, American Cancer Society, the NIH (…
Tumor Association, the James S. McDonnell Foundation, American Cancer Society, the NIH (…