User profiles for M. K. Aghi

Manish Aghi

Verified email at neurosurg.ucsf.edu
Cited by 30273

Application of novel response/progression measures for surgically delivered therapies for gliomas: Response Assessment in Neuro-Oncology (RANO) Working Group

MA Vogelbaum, S Jost, MK Aghi, AB Heimberger… - …, 2012 - journals.lww.com
BACKGROUND: The Response Assessment in Neuro-Oncology (RANO) Working Group is
an international, multidisciplinary effort to develop new standardized response criteria for …

Biology of angiogenesis and invasion in glioma

MC Tate, MK Aghi - Neurotherapeutics, 2009 - Elsevier
Treatment of adult brain tumors, in particular glioblastoma, remains a significant clinical
challenge, despite modest advances in surgical technique, radiation, and chemotherapeutics. …

Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy

YL Hu, A Jahangiri, M DeLay, MK Aghi - Cancer research, 2012 - AACR
Autophagy is a lysosomal degradation pathway that can sequester cytosolic material, including
organelles, nonspecifically in a process called nonselective macroautophagy, or target …

[PDF][PDF] VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex

…, JP Chang, CA Parachoniak, MM Pandika, MK Aghi… - Cancer cell, 2012 - cell.com
Inhibition of VEGF signaling leads to a proinvasive phenotype in mouse models of glioblastoma
multiforme (GBM) and in a subset of GBM patients treated with bevacizumab. Here, we …

Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma

…, AM Molinaro, SD Rose, WS Carbonell, MK Aghi - Cancer research, 2012 - AACR
Antiangiogenic therapy leads to devascularization that limits tumor growth. However, the
benefits of angiogenesis inhibitors are typically transient and resistance often develops. In this …

Impact of extent of resection for recurrent glioblastoma on overall survival

O Bloch, SJ Han, S Cha, MZ Sun, MK Aghi… - Journal of …, 2012 - thejns.org
Object Extent of resection (EOR) has been shown to be an important prognostic factor for
survival in patients undergoing initial resection of glioblastoma (GBM), but the significance of …

Long-term recurrence rates of atypical meningiomas after gross total resection with or without postoperative adjuvant radiation

MK Aghi, BS Carter, GR Cosgrove, RG Ojemann… - …, 2009 - journals.lww.com
Aghi et al. undertook a retrospective review of 108 atypical meningiomas after gross total
resection over an 11-year period at the Massachusetts General Hospital. This is an important …

The phenotypes of proliferating glioblastoma cells reside on a single axis of variation

…, S Shah, H Wadhwa, SM Chang, JJ Phillips, MK Aghi… - Cancer discovery, 2019 - AACR
Tumor-propagating cells can be derived from mesenchymal and proneural glioblastomas.
However, a stem cell of the classic subtype has yet to be demonstrated. We show that classic-…

Heat-shock protein peptide complex–96 vaccination for recurrent glioblastoma: a phase II, single-arm trial

O Bloch, CA Crane, Y Fuks, R Kaur, MK Aghi… - Neuro …, 2014 - academic.oup.com
Background Outcomes for patients with recurrent glioblastoma multiforme (GBM) are poor
and may be improved by immunotherapy. We investigated the safety and efficacy of an …

Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance

…, MM Chaumeil, SM Ronen, G Bergers, MK Aghi - Clinical Cancer …, 2013 - AACR
… This work was supported by funding to MK Aghi's laboratory from the American Brain
Tumor Association, the James S. McDonnell Foundation, American Cancer Society, the NIH (…