Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members
regulate cell-signaling cascades. Several OTU DUBs were reported to be ubiquitin (Ub) …

The linear ubiquitin (Ub) chain assembly complex (LUBAC) is an E3 ligase that specifically
assembles Met1-linked (also known as linear) Ub chains that regulate nuclear factor κB (NF-…

Pili are crucial virulence factors for many Gram-negative pathogens. These surface structures
provide bacteria with a link to their external environments by enabling them to interact with, …

Protein ubiquitination is a versatile protein modification that regulates virtually all cellular
processes. This versatility originates from polyubiquitin chains, which can be linked in eight …

Several ubiquitin chain types have remained unstudied, mainly because tools and techniques
to detect these posttranslational modifications are scarce. Linkage-specific antibodies …

Ubiquitin (Ub) chains regulate many cellular processes, but several chain types including Lys6
linkages have remained unstudied. Here we analyze the bacterial effector E3 ligase NleL …

Ubiquitin chains are important post-translational modifications that control a large number of
cellular processes. Chains can be formed via different linkages, which determines the type …

Types 1 and P pili are prototypical bacterial cell-surface appendages playing essential roles
in mediating adhesion of bacteria to the urinary tract. These pili, assembled by the …

Legionella pneumophila is a bacterial pathogen that utilises a Type IV secretion (T4S)
system to inject effector proteins into human macrophages. Essential to the recruitment and …

Adhesive chaperone-usher pili are long, supramolecular protein fibers displayed on the
surface of many bacterial pathogens. The type 1 and P pili of uropathogenic Escherichia coli (…