User profiles for M. L. Krishnan
Michelle Louise KrishnanNovartis Gene Therapies Verified email at novartis.com Cited by 1143 |
[HTML][HTML] Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus
…, J Behmoaras, L Bottolo, ML Krishnan… - Nature …, 2015 - nature.com
Gene-regulatory network analysis is a powerful approach to elucidate the molecular
processes and pathways underlying complex disease. Here we employ systems genetics …
processes and pathways underlying complex disease. Here we employ systems genetics …
Relationship between white matter apparent diffusion coefficients in preterm infants at term-equivalent age and developmental outcome at 2 years
ML Krishnan, LE Dyet, JP Boardman, O Kapellou… - …, 2007 - publications.aap.org
OBJECTIVE. The aim of this study was to develop a simple reproducible method for the
measurement of apparent diffusion coefficient values in the white matter of preterm infants using …
measurement of apparent diffusion coefficient values in the white matter of preterm infants using …
Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia
…, FM Oeschger, ML Krishnan… - Proceedings of the …, 2013 - National Acad Sciences
The subplate zone is a highly dynamic transient sector of the developing cerebral cortex
that contains some of the earliest generated neurons and the first functional synapses of the …
that contains some of the earliest generated neurons and the first functional synapses of the …
Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain
… At P30 mice were transaortically perfused with 20 ml saline followed by 100 ml of ice-cold
2% paraformaldehyde with 2% glutaraldehyde in 0.1 M phosphate buffer, pH 7.4 (PB). Brains …
2% paraformaldehyde with 2% glutaraldehyde in 0.1 M phosphate buffer, pH 7.4 (PB). Brains …
[HTML][HTML] Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants
Preterm birth places infants in an adverse environment that leads to abnormal brain
development and cerebral injury through a poorly understood mechanism known to involve …
development and cerebral injury through a poorly understood mechanism known to involve …
[HTML][HTML] Angelman syndrome genotypes manifest varying degrees of clinical severity and developmental impairment
Angelman Syndrome (AS) is a severe neurodevelopmental disorder due to impaired
expression of UBE3A in neurons. There are several genetic mechanisms that impair UBE3A …
expression of UBE3A in neurons. There are several genetic mechanisms that impair UBE3A …
[HTML][HTML] Measuring what matters to individuals with Angelman syndrome and their families: development of a patient-centered disease concept model
T Willgoss, D Cassater, S Connor, ML Krishnan… - Child Psychiatry & …, 2021 - Springer
Angelman syndrome (AS) is a complex, heterogeneous, and life-long neurodevelopmental
disorder. Despite the considerable impact on individuals and caregivers, no disease-…
disorder. Despite the considerable impact on individuals and caregivers, no disease-…
Diffusion features of white matter in tuberous sclerosis with tractography
Normal-appearing white matter has been shown via diffusion tensor imaging to be affected
in tuberous sclerosis complex. Under the hypothesis that some systems might be …
in tuberous sclerosis complex. Under the hypothesis that some systems might be …
Common genetic variants and risk of brain injury after preterm birth
… assays, genotyping experiments, QA tests, collation of data output, and generation of summary
statistics) and revised the manuscript for important intellectual content; Dr Krishnan made …
statistics) and revised the manuscript for important intellectual content; Dr Krishnan made …
Structural and optical studies of rare earth-free bismuth silicate glasses for white light generation
ML Krishnan, MM Neethish, VVRK Kumar - Journal of Luminescence, 2018 - Elsevier
We report here rare-earth free bismuth silicate based oxyfluoride glasses (70-x) Bi 2 O 3
30SiO 2 xMF (where M = Li, Na & K) with x = 5, 20 & 30 mol% that realizes white light. Bismuth …
30SiO 2 xMF (where M = Li, Na & K) with x = 5, 20 & 30 mol% that realizes white light. Bismuth …