User profiles for M. L. Krishnan

Michelle Louise Krishnan

Novartis Gene Therapies
Verified email at novartis.com
Cited by 1143

[HTML][HTML] Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

…, J Behmoaras, L Bottolo, ML Krishnan… - Nature …, 2015 - nature.com
Gene-regulatory network analysis is a powerful approach to elucidate the molecular
processes and pathways underlying complex disease. Here we employ systems genetics …

Relationship between white matter apparent diffusion coefficients in preterm infants at term-equivalent age and developmental outcome at 2 years

ML Krishnan, LE Dyet, JP Boardman, O Kapellou… - …, 2007 - publications.aap.org
OBJECTIVE. The aim of this study was to develop a simple reproducible method for the
measurement of apparent diffusion coefficient values in the white matter of preterm infants using …

Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia

…, FM Oeschger, ML Krishnan… - Proceedings of the …, 2013 - National Acad Sciences
The subplate zone is a highly dynamic transient sector of the developing cerebral cortex
that contains some of the earliest generated neurons and the first functional synapses of the …

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain

J Van Steenwinckel, AL Schang, ML Krishnan… - Brain, 2019 - academic.oup.com
… At P30 mice were transaortically perfused with 20 ml saline followed by 100 ml of ice-cold
2% paraformaldehyde with 2% glutaraldehyde in 0.1 M phosphate buffer, pH 7.4 (PB). Brains …

[HTML][HTML] Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants

ML Krishnan, J Van Steenwinckel, AL Schang… - Nature …, 2017 - nature.com
Preterm birth places infants in an adverse environment that leads to abnormal brain
development and cerebral injury through a poorly understood mechanism known to involve …

[HTML][HTML] Angelman syndrome genotypes manifest varying degrees of clinical severity and developmental impairment

M Keute, MT Miller, ML Krishnan, A Sadhwani… - Molecular …, 2021 - nature.com
Angelman Syndrome (AS) is a severe neurodevelopmental disorder due to impaired
expression of UBE3A in neurons. There are several genetic mechanisms that impair UBE3A …

[HTML][HTML] Measuring what matters to individuals with Angelman syndrome and their families: development of a patient-centered disease concept model

T Willgoss, D Cassater, S Connor, ML Krishnan… - Child Psychiatry & …, 2021 - Springer
Angelman syndrome (AS) is a complex, heterogeneous, and life-long neurodevelopmental
disorder. Despite the considerable impact on individuals and caregivers, no disease-…

Diffusion features of white matter in tuberous sclerosis with tractography

ML Krishnan, O Commowick, SS Jeste, N Weisenfeld… - Pediatric …, 2010 - Elsevier
Normal-appearing white matter has been shown via diffusion tensor imaging to be affected
in tuberous sclerosis complex. Under the hypothesis that some systems might be …

Common genetic variants and risk of brain injury after preterm birth

…, A Walley, G Ball, P Takousis, ML Krishnan… - …, 2014 - publications.aap.org
… assays, genotyping experiments, QA tests, collation of data output, and generation of summary
statistics) and revised the manuscript for important intellectual content; Dr Krishnan made …

Structural and optical studies of rare earth-free bismuth silicate glasses for white light generation

ML Krishnan, MM Neethish, VVRK Kumar - Journal of Luminescence, 2018 - Elsevier
We report here rare-earth free bismuth silicate based oxyfluoride glasses (70-x) Bi 2 O 3
30SiO 2 xMF (where M = Li, Na & K) with x = 5, 20 & 30 mol% that realizes white light. Bismuth …