Developmental roles of the histone lysine demethylases
A Nottke, MP Colaiácovo, Y Shi - 2009 - journals.biologists.com
Since the discovery of the first histone lysine demethylase in 2004, two protein families with
numerous members have been identified that demethylate various histone lysine residues. …
numerous members have been identified that demethylate various histone lysine residues. …
Meiotic Development in Caenorhabditis elegans
DY Lui, MP Colaiácovo - Germ Cell Development in C. elegans, 2013 - Springer
Caenorhabditis elegans has become a powerful experimental organism with which to study
meiotic processes that promote the accurate segregation of chromosomes during the …
meiotic processes that promote the accurate segregation of chromosomes during the …
Zipping and unzipping: protein modifications regulating synaptonemal complex dynamics
J Gao, MP Colaiácovo - Trends in Genetics, 2018 - cell.com
The proteinaceous zipper-like structure known as the synaptonemal complex (SC), which
forms between pairs of homologous chromosomes during meiosis from yeast to humans, plays …
forms between pairs of homologous chromosomes during meiosis from yeast to humans, plays …
Heritable genome editing in C. elegans via a CRISPR-Cas9 system
We report the use of clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated
endonuclease Cas9 to target genomic sequences in the Caenorhabditis elegans …
endonuclease Cas9 to target genomic sequences in the Caenorhabditis elegans …
REST and stress resistance in ageing and Alzheimer's disease
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve
function and protect against neurodegeneration during ageing are unknown. Here we show that …
function and protect against neurodegeneration during ageing are unknown. Here we show that …
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
…, KE Hurov, SP Gygi, MP Colaiácovo… - Proceedings of the …, 2010 - National Acad Sciences
Many proteins that respond to DNA damage are recruited to DNA lesions. We used a
proteomics approach that coupled isotopic labeling with chromatin fractionation and mass …
proteomics approach that coupled isotopic labeling with chromatin fractionation and mass …
[PDF][PDF] Synaptonemal complex assembly in C. elegans is dispensable for loading strand-exchange proteins but critical for proper completion of recombination
MP Colaiácovo, AJ MacQueen, E Martinez-Perez… - Developmental cell, 2003 - cell.com
Here we probe the relationships between assembly of the synaptonemal complex (SC) and
progression of recombination between homologous chromosomes during Caenorhabditis …
progression of recombination between homologous chromosomes during Caenorhabditis …
Synapsis-dependent and-independent mechanisms stabilize homolog pairing during meiotic prophase in C. elegans
AJ MacQueen, MP Colaiácovo… - Genes & …, 2002 - genesdev.cshlp.org
Analysis of Caenorhabditis elegans syp-1 mutants reveals that both synapsis-dependent
and -independent mechanisms contribute to stable, productive alignment of homologous …
and -independent mechanisms contribute to stable, productive alignment of homologous …
Regulation of lifespan by neural excitation and REST
…, A Rotenberg, DA Bennett, GM Church, MP Colaiácovo… - Nature, 2019 - nature.com
The mechanisms that extend lifespan in humans are poorly understood. Here we show that
extended longevity in humans is associated with a distinct transcriptome signature in the …
extended longevity in humans is associated with a distinct transcriptome signature in the …
Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities
P Allard, MP Colaiácovo - Proceedings of the National …, 2010 - National Acad Sciences
Bisphenol A (BPA) is a highly prevalent constituent of plastics that has been associated with
diabetes, cardiovascular disease, and an increased risk of miscarriages in humans. In mice, …
diabetes, cardiovascular disease, and an increased risk of miscarriages in humans. In mice, …