Since the discovery of the first histone lysine demethylase in 2004, two protein families with
numerous members have been identified that demethylate various histone lysine residues. …

Caenorhabditis elegans has become a powerful experimental organism with which to study
meiotic processes that promote the accurate segregation of chromosomes during the …

The proteinaceous zipper-like structure known as the synaptonemal complex (SC), which
forms between pairs of homologous chromosomes during meiosis from yeast to humans, plays …

We report the use of clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated
endonuclease Cas9 to target genomic sequences in the Caenorhabditis elegans …

Human neurons are functional over an entire lifetime, yet the mechanisms that preserve
function and protect against neurodegeneration during ageing are unknown. Here we show that …

Many proteins that respond to DNA damage are recruited to DNA lesions. We used a
proteomics approach that coupled isotopic labeling with chromatin fractionation and mass …

Here we probe the relationships between assembly of the synaptonemal complex (SC) and
progression of recombination between homologous chromosomes during Caenorhabditis …

Analysis of Caenorhabditis elegans syp-1 mutants reveals that both synapsis-dependent
and -independent mechanisms contribute to stable, productive alignment of homologous …

The Fanconi anemia (FA) pathway is responsible for interstrand crosslink repair. At the heart
of this pathway is the FANCI-FAND2 (ID) complex, which, upon ubiquitination by the FA …

The mechanisms that extend lifespan in humans are poorly understood. Here we show that
extended longevity in humans is associated with a distinct transcriptome signature in the …