User profiles for M. P. Gillum
Matthew P. GillumAssociate Professor, Novo Nordisk Foundation Center for Basic Metabolic Research … Verified email at sund.ku.dk Cited by 3583 |
Sirtuin-1 regulation of mammalian metabolism
MP Gillum, DM Erion, GI Shulman - Trends in molecular medicine, 2011 - cell.com
Sirtuin-1 (SirT1) is a nutrient-sensing deacetylase whose levels and activity increase with
caloric restriction to preserve euglycemia and promote efficient energy utilization. Focusing on …
caloric restriction to preserve euglycemia and promote efficient energy utilization. Focusing on …
[PDF][PDF] FGF21 mediates endocrine control of simple sugar intake and sweet taste preference by the liver
The liver is an important integrator of nutrient metabolism, yet no liver-derived factors regulating
nutrient preference or carbohydrate appetite have been identified. Here we show that …
nutrient preference or carbohydrate appetite have been identified. Here we show that …
SirT1 regulates adipose tissue inflammation
MP Gillum, ME Kotas, DM Erion, R Kursawe… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Macrophage recruitment to adipose tissue is a reproducible feature of obesity.
However, the events that result in chemokine production and macrophage recruitment to …
However, the events that result in chemokine production and macrophage recruitment to …
[PDF][PDF] FGF21 is a sugar-induced hormone associated with sweet intake and preference in humans
The liking and selective ingestion of palatable foods—including sweets—is biologically
controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease…
controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease…
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
Hepatic gluconeogenesis is a major contributing factor to hyperglycemia in the fasting and
postprandial states in type 2 diabetes mellitus (T2DM). Because Sirtuin 1 (SirT1) induces …
postprandial states in type 2 diabetes mellitus (T2DM). Because Sirtuin 1 (SirT1) induces …
Fibroblast growth factor 21: an endocrine inhibitor of sugar and alcohol appetite
S von Holstein‐Rathlou, MP Gillum - The Journal of physiology, 2019 - Wiley Online Library
… Through her master thesis work, she contributed to the understanding of the regulatory role
of FGF21 in sugar ingestion in the laboratory of Dr Gillum. Currently, she is enrolled in a PhD …
of FGF21 in sugar ingestion in the laboratory of Dr Gillum. Currently, she is enrolled in a PhD …
[HTML][HTML] N-acylphosphatidylethanolamine, a gut-derived circulating factor induced by fat ingestion, inhibits food intake
MP Gillum, D Zhang, XM Zhang, DM Erion, RA Jamison… - Cell, 2008 - cell.com
N-acylphosphatidylethanolamines (NAPEs) are a relatively abundant group of plasma lipids
of unknown physiological significance. Here, we show that NAPEs are secreted into …
of unknown physiological significance. Here, we show that NAPEs are secreted into …
[PDF][PDF] Cardiolipin synthesis in brown and beige fat mitochondria is essential for systemic energy homeostasis
Activation of energy expenditure in thermogenic fat is a promising strategy to improve metabolic
health, yet the dynamic processes that evoke this response are poorly understood. Here …
health, yet the dynamic processes that evoke this response are poorly understood. Here …
[PDF][PDF] FGF21 signals to glutamatergic neurons in the ventromedial hypothalamus to suppress carbohydrate intake
Fibroblast growth factor 21 (FGF21) is an endocrine hormone produced by the liver that
regulates nutrient and metabolic homeostasis. FGF21 production is increased in response to …
regulates nutrient and metabolic homeostasis. FGF21 production is increased in response to …
[HTML][HTML] Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis
Objective Glucagon is well known to regulate blood glucose but may be equally important
for amino acid metabolism. Plasma levels of amino acids are regulated by glucagon-…
for amino acid metabolism. Plasma levels of amino acids are regulated by glucagon-…