User profiles for M. R. Saathoff
Miranda SaathoffNorthwestern University Verified email at northwestern.edu Cited by 179 |
Activation of dopamine receptor 2 prompts transcriptomic and metabolic plasticity in glioblastoma
…, S Baisiwala, CH Park, MR Saathoff… - Journal of …, 2019 - Soc Neuroscience
Glioblastoma (GBM) is one of the most aggressive and lethal tumor types. Evidence
continues to accrue indicating that the complex relationship between GBM and the brain …
continues to accrue indicating that the complex relationship between GBM and the brain …
De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma
Glioblastoma is a primary brain cancer with a near 100% recurrence rate. Upon recurrence,
the tumour is resistant to all conventional therapies, and because of this, 5-year survival is …
the tumour is resistant to all conventional therapies, and because of this, 5-year survival is …
[HTML][HTML] Chemotherapeutic stress induces transdifferentiation of glioblastoma cells to endothelial cells and promotes vascular mimicry
…, R Ahsan, G Lee, T Hasan, C Park, MR Saathoff… - Stem cells …, 2019 - hindawi.com
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor
affecting adults, with a median survival of approximately 21 months. One key factor underlying …
affecting adults, with a median survival of approximately 21 months. One key factor underlying …
[HTML][HTML] LNX1 modulates Notch1 signaling to promote expansion of the glioma stem cell population during temozolomide therapy in glioblastoma
Simple Summary Glioblastoma is the most common adult malignant brain tumor. It is an
aggressive tumor that returns even after surgical removal and temozolomide-based …
aggressive tumor that returns even after surgical removal and temozolomide-based …
Spelling Out CICs: A Multi-Organ Examination of the Contributions of Cancer Initiating Cells' Role in Tumor Progression
Tumor invasion and metastasis remain the leading causes of mortality for patients with
cancer despite current treatment strategies. In some cancer types, recurrence is considered …
cancer despite current treatment strategies. In some cancer types, recurrence is considered …
The generation of peak pressures in separated/reattaching flows
PJ Saathoff, WH Melbourne - Journal of Wind Engineering and Industrial …, 1989 - Elsevier
An experimental study was conducted to investigate the occurrence of large negative peak
pressures near the leading edge of sharp-edged bluff bodies. Flow visualization experiments …
pressures near the leading edge of sharp-edged bluff bodies. Flow visualization experiments …
Effects of free-stream turbulence on surface pressure fluctuations in a separation bubble
PJ Saathoff, WH Melbourne - Journal of Fluid Mechanics, 1997 - cambridge.org
Wind-tunnel experiments were conducted to investigate the cause of large pressure fluctuations
near leading edges of sharp-edged bluff bodies. Measurements obtained with a blunt …
near leading edges of sharp-edged bluff bodies. Measurements obtained with a blunt …
CRISPR-Cas9 Screen Reveals PSMB3 Contributes to Gliomagenesis Through Proteasome-Dependent and Independent Mechanisms
…, L Chen, CH Park, EN Perrault, MR Saathoff… - bioRxiv, 2021 - biorxiv.org
Glioblastoma (GBM) is the most common adult malignant brain tumor, with a median survival
of 21 months and a 100% recurrence rate. Even though many of the critical oncogenic …
of 21 months and a 100% recurrence rate. Even though many of the critical oncogenic …
Identifying a novel network of driver genes in glioblastoma
…, C Park, C Awah, JM Shireman, MR Saathoff… - Cancer Research, 2020 - AACR
The purpose of this study is to identify novel genes that drive proliferation in glioblastoma (GBM)
and likely contribute to gliomagenesis, therefore facilitating the aggressive nature of the …
and likely contribute to gliomagenesis, therefore facilitating the aggressive nature of the …
Abstract B034: Targeting cellular plasticity-driven metabolic adaptation to overcome chemoresistance in GBM
…, JM Shireman, F Atash, G Lee, ES Ali, MR Saathoff… - Cancer Research, 2022 - AACR
This abstract is being presented as a short talk in the scientific program. A full abstract is
available in the Proffered Abstracts section (PR011) of the Conference Proceedings. Citation …
available in the Proffered Abstracts section (PR011) of the Conference Proceedings. Citation …