User profiles for M. R. Saathoff

Miranda Saathoff

Northwestern University
Verified email at northwestern.edu
Cited by 179

Activation of dopamine receptor 2 prompts transcriptomic and metabolic plasticity in glioblastoma

…, S Baisiwala, CH Park, MR Saathoff… - Journal of …, 2019 - Soc Neuroscience
Glioblastoma (GBM) is one of the most aggressive and lethal tumor types. Evidence
continues to accrue indicating that the complex relationship between GBM and the brain …

De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma

JM Shireman, F Atashi, G Lee, ES Ali, MR Saathoff… - Brain, 2021 - academic.oup.com
Glioblastoma is a primary brain cancer with a near 100% recurrence rate. Upon recurrence,
the tumour is resistant to all conventional therapies, and because of this, 5-year survival is …

[HTML][HTML] Chemotherapeutic stress induces transdifferentiation of glioblastoma cells to endothelial cells and promotes vascular mimicry

…, R Ahsan, G Lee, T Hasan, C Park, MR Saathoff… - Stem cells …, 2019 - hindawi.com
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor
affecting adults, with a median survival of approximately 21 months. One key factor underlying …

[HTML][HTML] LNX1 modulates Notch1 signaling to promote expansion of the glioma stem cell population during temozolomide therapy in glioblastoma

S Baisiwala, RR Hall III, MR Saathoff, J M. Shireman… - Cancers, 2020 - mdpi.com
Simple Summary Glioblastoma is the most common adult malignant brain tumor. It is an
aggressive tumor that returns even after surgical removal and temozolomide-based …

Spelling Out CICs: A Multi-Organ Examination of the Contributions of Cancer Initiating Cells' Role in Tumor Progression

…, C Goel, KR Nandoliya, MR Saathoff… - Stem cell reviews and …, 2021 - Springer
Tumor invasion and metastasis remain the leading causes of mortality for patients with
cancer despite current treatment strategies. In some cancer types, recurrence is considered …

The generation of peak pressures in separated/reattaching flows

PJ Saathoff, WH Melbourne - Journal of Wind Engineering and Industrial …, 1989 - Elsevier
An experimental study was conducted to investigate the occurrence of large negative peak
pressures near the leading edge of sharp-edged bluff bodies. Flow visualization experiments …

Effects of free-stream turbulence on surface pressure fluctuations in a separation bubble

PJ Saathoff, WH Melbourne - Journal of Fluid Mechanics, 1997 - cambridge.org
Wind-tunnel experiments were conducted to investigate the cause of large pressure fluctuations
near leading edges of sharp-edged bluff bodies. Measurements obtained with a blunt …

CRISPR-Cas9 Screen Reveals PSMB3 Contributes to Gliomagenesis Through Proteasome-Dependent and Independent Mechanisms

…, L Chen, CH Park, EN Perrault, MR Saathoff… - bioRxiv, 2021 - biorxiv.org
Glioblastoma (GBM) is the most common adult malignant brain tumor, with a median survival
of 21 months and a 100% recurrence rate. Even though many of the critical oncogenic …

Identifying a novel network of driver genes in glioblastoma

…, C Park, C Awah, JM Shireman, MR Saathoff… - Cancer Research, 2020 - AACR
The purpose of this study is to identify novel genes that drive proliferation in glioblastoma (GBM)
and likely contribute to gliomagenesis, therefore facilitating the aggressive nature of the …

Abstract B034: Targeting cellular plasticity-driven metabolic adaptation to overcome chemoresistance in GBM

…, JM Shireman, F Atash, G Lee, ES Ali, MR Saathoff… - Cancer Research, 2022 - AACR
This abstract is being presented as a short talk in the scientific program. A full abstract is
available in the Proffered Abstracts section (PR011) of the Conference Proceedings. Citation …