Background. Delayed postoperative paraplegia is a recognized complication of thoracic (TAA)
or thoracoabdominal aortic aneurysm (TAAA) repair. The purpose of this study was to …

Effective public response to a pandemic relies upon accurate measurement of the extent and
dynamics of an outbreak. Viral genome sequencing has emerged as a powerful approach …

Sox2 expression in mouse embryonic stem cells (mESCs) depends on a distal cluster of
DNase I hypersensitive sites (DHSs), but their individual contributions and degree of …

Drug development and biological discovery require effective strategies to map existing
genetic associations to causal genes. To approach this problem, we selected 12 common …

Routine rewriting of loci associated with human traits and diseases would facilitate their
functional analysis. However, existing DNA integration approaches are limited in terms of …

Abstract Design and large-scale synthesis of DNA has been applied to the functional study
of viral and microbial genomes. New and expanded technology development is required to …

The relationship between chromatin organization and transcriptional regulation is an area of
intense investigation. We characterized the spatial relationships between alleles of the Oct4…

The specificity of interactions between genomic regulatory elements and potential target
genes is influenced by the binding of insulator proteins such as CTCF, which can act as potent …

Our molecular understanding of the cystic fibrosis transmembrane conductance regulator (CFTR)—the
chloride channel that is mutated in cystic fibrosis—has been greatly enhanced by …

Functional assessment of disease-associated sequence variation at non-coding regulatory
elements is complicated by their high degree of context sensitivity to both the local chromatin …