Background Tumor progression is accompanied by dramatic remodeling of the surrounding
extracellular matrix leading to the formation of a tumor-specific ECM, which is often more …

… We thank Rasmus Siersbæk and Niels Mahler Kristiansen as well as other members of the
Mandrup laboratory for experimental support and fruitful discussions. Furthermore, we are …

Peroxisome proliferator-activated receptor γ (PPARγ) is a master regulator of adipocyte
differentiation and function. We and others have previously mapped PPARγ binding at a genome-…

Thyroid hormone (TH) and TH receptors (TRs) α and β act by binding to TH response elements
(TREs) in regulatory regions of target genes. This nuclear signaling is established as the …

Physiologic turnover of interstitial collagen is mediated by a sequential pathway in which
collagen is fragmented by pericellular collagenases, endocytosed by collagen receptors, and …

C57BL/6J-related mouse strains are widely used animal models for diet-induced obesity (DIO).
Multiple vendors breed C57BL/6J-related substrains which may introduce genetic drift …

Tumor-associated macrophages (TAMs) support tumor growth by suppressing the activity of
tumor-infiltrating T cells. Consistently, TAMs are considered a major limitation for the efficacy …

… Indira Chandran, Vineesh 1 ; Wernberg, Charlotte Wilhelmina 2,3 ; Lauridsen, Mette
Munk 2 ; Skytthe, Maria Kløjgaard 1 ; Bendixen, Sofie Marchsteiner 4 ; Larsen, Frederik …

The transcription factor MYC is overexpressed in most cancers, where it drives multiple
hallmarks of cancer progression. MYC is known to promote oncogenic transcription by binding to …

Hepatic circadian gene transcription is tightly coupled to feeding behavior, which has a
profound impact on metabolic disorders associated with diet-induced obesity. Here, we describe …