The mammalian brain contains neurogenic niches that comprise neural stem cells and other
cell types. Neurogenic niches become less functional with age, but how they change during …

The anti-inflammatory mechanism of sulfasalazine is not well understood. It has recently
been shown that sulfasalazine inhibits 5-aminoimidazole-4-carboxamidoribonucleotide (AICAR…

The diversity of cell types is a challenge for quantifying aging and its reversal. Here we
develop ‘aging clocks’ based on single-cell transcriptomics to characterize cell-type-specific …

FADS genes encode fatty acid desaturases that are important for the conversion of short
chain polyunsaturated fatty acids (PUFAs) to long chain fatty acids. Prior studies indicate that …

Background Treatment options for patients with recurrent superficial bladder cancer are limited,
necessitating aggressive exploration of new treatment strategies that effectively prevent …

Exercise has the ability to rejuvenate stem cells and improve tissue regeneration in aging
animals. However, the cellular and molecular changes elicited by exercise have not been …

Increased androgen receptor (AR) expression and activity are pivotal for androgen-independent
(AI) prostate cancer (PC) progression and resistance to androgen-deprivation therapy. …

Alterations of the gut microbiota after allogeneic hematopoietic cell transplantation (allo-HCT)
are a key factor in the development of transplant-related complications such as graft-versus…

Interactions between the sexes negatively impact health in many species. In Caenorhabditis,
males shorten the lifespan of the opposite sex—hermaphrodites or females. Here we use …

Aging manifests as progressive dysfunction culminating in death. The diversity of cell types
is a challenge to the precise quantification of aging and its reversal. Here we develop a suite …