The human gut harbors native microbial communities, forming a highly complex ecosystem.
Synthetic microbial communities (SynComs) of the human gut are an assembly of …

Performance of industrial microorganisms as cell factories is limited by the capacity to
channel nutrients to desired products, of which optimal production usually requires careful …

Introduction Cells use multilayered regulatory systems to respond adequately to changing
environments or perturbations. Failure in regulation underlies cellular malfunctioning, loss of …

Although phenotypic plasticity can be advantageous in fluctuating environments, it may come
too late if the environment changes fast. Complementary chromatic adaptation is a colorful …

Microbes may maximize the number of daughter cells per time or per amount of nutrients
consumed. These two strategies correspond, respectively, to the use of enzyme-efficient or …

Evolution has traditionally been a historical and descriptive science, and predicting future
evolutionary processes has long been considered impossible. However, evolutionary …

Specific product formation rates and cellular growth rates are important maximization
targets in biotechnology and microbial evolution. Maximization of a specific rate (ie a rate …

Many organisms have several similar transporters with different affinities for the same
substrate. Typically, high-affinity transporters are expressed when substrate is scarce and low-…

Protein expression is shaped by evolutionary processes that tune microbial fitness. The
limited biosynthetic capacity of a cell constrains protein expression and forces the cell to …

High-throughput data generation and genome-scale stoichiometric models have greatly
facilitated the comprehensive study of metabolic networks. The computation of all feasible …