Structural basis for transcriptional start site control of HIV-1 RNA fate

…, Y Desai, L Glang, SH Choi, K Singh, MW Lopresti… - Science, 2020 - science.org
Heterogeneous transcriptional start site usage by HIV-1 produces 5′-capped RNAs beginning
with one, two, or three 5′-guanosines ( Cap 1G, Cap 2G, or Cap 3G, respectively) that …

[PDF][PDF] The antiviral and cancer genomic DNA deaminase APOBEC3H is regulated by an RNA-mediated dimerization mechanism

…, CM Richards, D Salamango, J Wang, MW Lopresti… - Molecular cell, 2018 - cell.com
Molecular weight standards are shown on the dashed line above chromatograms. (C)
Polyacrylamide-urea gel image of A3H preparations after proteinase K treatment. Wild-type, K52E, …

[HTML][HTML] Phosphatase PHLPP2 regulates the cellular response to metabolic stress through AMPK

…, KN Krecke, AS Bapat, T Yang, MW Lopresti… - Cell Death & …, 2021 - nature.com
PHLPP2 is a member of the PHLPP family of phosphatases, known to suppress cell growth
by inhibiting proliferation or promoting apoptosis. Oncogenic kinases Akt, S6K, and PKC, and …

[HTML][HTML] Hepatic lysosomal acid lipase overexpression worsens hepatic inflammation in mice fed a Western diet

MW Lopresti, W Cui, BE Abernathy, G Fredrickson… - Journal of lipid …, 2021 - ASBMB
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of lipid droplets
in hepatocytes. NAFLD development and progression is associated with an increase in …

Polymersomes: nature inspired nanometer sized compartments

C LoPresti, H Lomas, M Massignani, T Smart… - Journal of Materials …, 2009 - pubs.rsc.org
… Small scale fusion with low molecular weight PEO and jamming with higher molecular
weight PEO are visible with a critical PEO molecular weight of 4000 Da. (C) Confocal laser …

Controlling cellular uptake by surface chemistry, size, and surface topology at the nanoscale

M Massignani, C LoPresti, A Blanazs, J Madsen… - small, 2009 - Wiley Online Library
… In particular, polymersomes are much more stable than their low-molecular-weight
counterparts20 and in vivo experiments have confirmed much longer circulation times than PEG-…

Structure–property relationship and controlled drug release from multiphasic electrospun carvacrol-embedded polylactic acid/polyethylene glycol and polylactic acid …

…, FE Gulino, F Lopresti - Journal of Industrial …, 2020 - journals.sagepub.com
… glycol (PEG) if Mw < 20,000 Da or polyethylene oxide (PEO) if Mw > 20,000 Da. These blends
… PEG is an hydrosoluble polymer partially miscible in PLA whose molecular weight can …

Polysaccharide nanocrystals as fillers for PLA based nanocomposites

R Scaffaro, L Botta, F Lopresti, A Maio, F Sutera - Cellulose, 2017 - Springer
… groups leads to a decrease of molecular weight; in the second, the molecular weight is
reduced until the lactic acid and low molecular weight oligomers are naturally metabolized by …

Preparation, characterization and hydrolytic degradation of PLA/PCL co-mingled nanofibrous mats prepared via dual-jet electrospinning

R Scaffaro, F Lopresti, L Botta - European Polymer Journal, 2017 - Elsevier
… The changes in molecular weight of PCL and PLA for the three different degradation
conditions, … In alkaline environment (pH 10), the viscosimetric molecular weight of PCL and PLA …

Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes.

P LoPresti, S Szuchet… - Proceedings of the …, 1995 - National Acad Sciences
We present evidence that the microtubule-associated protein tau is present in oligodendrocytes
(OLGs), the central nervous system cells that make myelin. By showing that tau is …