PPARγ signaling and metabolism: the good, the bad and the future
Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …
Regulation of lipolysis in adipocytes
RE Duncan, M Ahmadian, K Jaworski… - Annu. Rev …, 2007 - annualreviews.org
Lipolysis of white adipose tissue triacylglycerol stores results in the liberation of glycerol and
nonesterified fatty acids that are released into the vasculature for use by other organs as …
nonesterified fatty acids that are released into the vasculature for use by other organs as …
GTPase-activating proteins: helping hands to complement an active site
K Scheffzek, MR Ahmadian, A Wittinghofer - Trends in biochemical …, 1998 - cell.com
Stimulation of the intrinsic GTPase activity of GTP-binding proteins by GTPase-activating
proteins (GAPs) is a basic principle of GTP-binding-protein downregulation. Recently, the …
proteins (GAPs) is a basic principle of GTP-binding-protein downregulation. Recently, the …
A reliable deep representation learning to improve trust-aware recommendation systems
… = 2 × s i m u , v × t u , v s i m u , v + t u , v i f s i m u , v > 0 a n d t u , v > 0 t u , v i f s i m u , v ≤
0 a n d t u , v > 0 s i m u , v i f s i m u , v > 0 a n d t u , v ≤ 0 0 i f s i m u , v ≤ 0 a n d t u , v ≤ 0 …
0 a n d t u , v > 0 s i m u , v i f s i m u , v > 0 a n d t u , v ≤ 0 0 i f s i m u , v ≤ 0 a n d t u , v ≤ 0 …
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants
K Scheffzek, MR Ahmadian, W Kabsch, L Wiesmuller… - Science, 1997 - science.org
The three-dimensional structure of the complex between human H-Ras bound to guanosine
diphosphate and the guanosine triphosphatase (GTPase)–activating domain of the human …
diphosphate and the guanosine triphosphatase (GTPase)–activating domain of the human …
[HTML][HTML] CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
…, H Iven, PR Galle, MR Ahmadian… - The Journal of …, 2003 - Am Soc Clin Investig
… the JC-1 molecules that in turn depend on the ΔΨ m (the greater the ΔΨ m , the greater the
aggregation). Changes in ΔΨ m were measured by monitoring JC-1 fluorescence at 590 nm. …
aggregation). Changes in ΔΨ m were measured by monitoring JC-1 fluorescence at 590 nm. …
[PDF][PDF] Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype
M Ahmadian, MJ Abbott, T Tang, CSS Hudak, Y Kim… - Cell metabolism, 2011 - cell.com
While fatty acids (FAs) released by white adipose tissue (WAT) provide energy for other
organs, lipolysis is also critical in brown adipose tissue (BAT), generating FAs for oxidation and …
organs, lipolysis is also critical in brown adipose tissue (BAT), generating FAs for oxidation and …
On the size-dependent behavior of functionally graded micro-beams
In this paper, the size-dependent static and vibration behavior of micro-beams made of
functionally graded materials (FGMs) are analytically investigated on the basis of the modified …
functionally graded materials (FGMs) are analytically investigated on the basis of the modified …
RDERL: Reliable deep ensemble reinforcement learning-based recommender system
… − 1 + l m − l m + 1 i f l m + 1 > l m where A m and A ˆ ( m ) refer to the … m , respectively, n is
the number of ratings in each set of A m and A ˆ ( m ) , and l m is the loss value of the state m . …
the number of ratings in each set of A m and A ˆ ( m ) , and l m is the loss value of the state m . …
A nonlinear Timoshenko beam formulation based on the modified couple stress theory
This paper presents a nonlinear size-dependent Timoshenko beam model based on the
modified couple stress theory, a non-classical continuum theory capable of capturing the size …
modified couple stress theory, a non-classical continuum theory capable of capturing the size …