Although originally identified as putative negative regulators of the cell cycle, recent studies
have demonstrated that the PHB proteins act as a chaperone in the assembly of subunits of …

… implicated in regulating membrane protein degradation by the mitochondrial m-AAA protease
[ … The PHB complex may assist with protein folding and assembly in cooperation with the m-…

Drug discovery and drug target identification are two intimately linked facets of intervention
strategies aimed at effectively combating pathological conditions in humans. Simple model …

… Approximately 200 μg of protein extract in 350 μl of sample buffer containing 7 M urea (Sigma),
2 M thiourea (Sigma), 4% CHAPS (Sigma), 100 mM dithiothreitol (Sigma… Marta Artal-Sanz …

… Marta Artal-Sanz and Nektarios Tavernarakis now show that prohibitin increases lifespan
of the nematode worm Caenorhabditis elegans by modulating mitochondrial function and fat …

… Author links open overlay panel Marta Artal-Sanz , Nektarios Tavernarakis … As discussed
above, mouse m-calpain plays an important role during early development [57], and calpains …

… Marta Artal-Sanz … M. Artal-Sanz is supported by a Marie Curie postdoctoral fellowship (FP6-EIF).
N. Tavernarakis is an EMBO Young Investigator. …

Mitochondrial functions are essential for life, critical for development, maintenance of stem
cells, adaptation to physiological changes, responses to stress, and aging. The complexity of …

Iron is an essential micronutrient for all forms of life; low levels of iron cause human disease,
while too much iron is toxic. Low iron levels induce reactive oxygen species (ROS) by …

Caenorhabditis elegans postembryonic development consists of four discrete larval stages
separated by molts. Typically, the speed of progression through these larval stages is …