OBJECTIVE: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist
in disease diagnosis and assessment of disease severity, risk of onset, and progression. …

Osteoarthritis is often a progressive and disabling disease, which occurs in the setting of a
variety of risk factors – such as advancing age, obesity, and trauma – that conspire to incite a …

Osteoarthritis (OA) is a degenerative joint disease that progressively causes loss of joint
function and is the leading source of physical disability and impaired quality of life in …

Objective To characterize the diversity and taxonomic relative abundance of the gut
microbiota in patients with never‐treated, recent‐onset psoriatic arthritis (PsA). Methods High‐…

Objective To profile the abundance and diversity of subgingival oral microbiota in patients
with never‐treated, new‐onset rheumatoid arthritis (RA). Methods Periodontal disease (PD) …

Tetracyclines have recently been shown to have “chondroprotective” effects in inflammatory
arthritides in animal models. Since nitric oxide (NO) is spontaneously released from human …

… The cartilage was milled into fine powder in liquid nitrogen and extracted with 4 M
guanidium thiocyanate, 25 mM sodium citrate, 0.5% sodium dodecyl sarcosine, and 0.1 M 2-…

T cell receptor (TCR)–dependent regulatory T cell (T reg ) activity controls effector T cell (T
eff ) function and is inhibited by the inflammatory cytokine tumor necrosis factor–α (TNF-α). …

… At the end of the experiment, 10 μCi/ml sodium sulfate (Na 2 35 SO 4 ) was added for 4 h
at 37 C in a 5% CO 2 atmosphere and explants were washed five times with 0.15 M NaCl and …

Nitric oxide synthesized by inducible nitric oxide synthase (iNOS) has been implicated as a
mediator of inflammation in rheumatic and autoimmune diseases. We report that exposure of …