Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its
early disease stages, its effects on biological processes or the transition to clinical T2D. To …

Precision health relies on the ability to assess disease risk at an individual level, detect early
preclinical conditions and initiate preventive strategies. Recent technological advances in …

… Amsallem., YK, WZ, and M. Avina contributed to data curation. KC, SW, FH, KJM, DH, and
MPS contributed to data visualization. KC, SW, KJM, DH, AAM, EW, SA, BB, MD, and DAK …

The molecular changes that occur with aging are not well understood 1 , 2 , 3 – 4 . Here, we
performed longitudinal and deep multiomics profiling of 106 healthy individuals from 29 to …

Lipids can be of endogenous or exogenous origin and affect diverse biological functions,
including cell membrane maintenance, energy management and cellular signalling. Here, we …

To understand the dynamic interplay between the human microbiome and host during health
and disease, we analyzed the microbial composition, temporal dynamics, and associations …

The SARS-CoV-2 virus was first identified in Wuhan, China, in late December 2019, and it
quickly spread to many countries. By March 2020, the virus had triggered a global pandemic (…

Background During the COVID-19 pandemic, public health measures such as isolation,
quarantine, and social distancing are needed. Some of these measures can adversely affect …

Exome sequencing is increasingly utilized in both clinical and nonclinical settings, but little
is known about its utility in healthy individuals. Most previous studies on this topic have …

… fumarate-emtricitabine (TDF/FTC) or abacavir-lamivudine, with efavirenz (EFV) or
atazanavir-ritonavir at standard doses] by a mean weight of 4.8 kg and mean BMI by 1.5 kg/m 2 after …