… Michael Batie is funded by a PhD studentship from the Medical Research Council (MRC).
Sonia … Laura D’Ignazio, Michael Batie and Sonia Rocha performed the literature review and …

… has shown that these enzymes have different K m values for oxygen [32]. Although the prolyl
hydroxylase K m value is approximately 230 μM O 2 , the FIH K m value for O 2 is only 90 …

… The ability of KDM4A to function as an O 2 sensor was supported by in vitro work with a
reported K M for oxygen of 173 µm (Table 1). Interestingly, work from the Hammond laboratory …

… Although the oxygen K m for KDM5A is currently unknown, our data suggest that this property
alone is insufficient to explain how different tissues respond to different oxygen tensions. …

… We used multiplex fluorescence in situ hybridization (M-FISH) to label distinct subpopulations
in the POA of P21 Opn5 cre/+ ;Ai14 mice (Fig. 1e): most Opn5 POA neurons expressed …

… l,m, Hoechst 33258-labelled hyaloid vessel preparations from P8 mice raised from birth in …
P values were determined by one-way ANOVA (e,r,v) and Student’s t-test (j,l,m). Error bars are …

Almost all life forms can detect and decode light information for adaptive advantage.
Examples include the visual system, in which photoreceptor signals are processed into virtual …

Background Food-induced anaphylaxis (FIA) is an IgE-dependent immune response that can
affect multiple organs and lead to life-threatening complications. The processes by which …

Stress is the most commonly reported precipitating factor for seizures in patients with epilepsy.
Despite compelling anecdotal evidence for stress-induced seizures, animal models of the …

Cellular adaptation to low-oxygen environments is mediated in part by the hypoxia-inducible
factors (HIFs). Like other transcription factors, the stability and transcriptional activity of HIFs…