Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …

HBV infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Although HBV
infection can be efficiently prevented by vaccination, and treatments are available, to date …

Objective: The Middle East and North Africa (MENA) region continues to be perceived as a
region with very limited HIV epidemiological data, raising many controversies about the …

The primate lentivirus auxiliary protein Vpx counteracts an unknown restriction factor that
renders human dendritic and myeloid cells largely refractory to HIV-1 infection 1 , 2 , 3 , 4 , 5 , 6 …

SAMHD1 restricts the infection of dendritic and other myeloid cells by human immunodeficiency
virus type 1 (HIV-1), but in lentiviruses of the simian immunodeficiency virus of sooty …

… to cytoplasmic extracts) were collected, and nuclear extracts were prepared by resuspending
pellets in 50 μl of 50 mm Hepes, pH 7.8, 50 mm KCl, 300 mmNaCl, 0.1 mm EDTA, 1 …

MicroRNAs (miRNAs) are single-stranded noncoding RNAs of 19 to 25 nucleotides that
function as gene regulators and as a host cell defense against both RNA and DNA viruses. We …

In plants and invertebrate animals, RNA silencing is a form of nucleic acid-based adaptive
immunity. By contrast, jawed vertebrates have evolved complex protein-based adaptive …

Chemokines and chemokine receptors play important roles in HIV-1 infection and tropism.
CCR5 is the major macrophage-tropic coreceptor for HIV-1 whereas CXC chemokine receptor …

… , 17% glycerol, 2 mM dithiothreitol (DTT)] containing 0.1 M KCl. Proteins were eluted with
buffer B containing 1 M KCl. The eluates were desalted and concentrated using 10 000 mol. wt …