Activation of cellular stress response pathways to maintain metabolic homeostasis is emerging
as a critical growth and survival mechanism in many cancers 1 . The pathogenesis of …

Single-cell technologies have described heterogeneity across tissues, but the spatial
distribution and forces that drive single-cell phenotypes have not been well defined. Combining …

Cyclin-dependent kinase 9 (CDK9), an important regulator of transcriptional elongation, is a
promising target for cancer therapy, particularly for cancers driven by transcriptional …

Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human
epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive …

INTRODUCTION The mammal has evolved an epigenetic mechanism to silence one of two
X chromosomes in the XX female to equalize gene dosages with the XY male. Once …

Intermediary metabolism generates substrates for chromatin modification, enabling the
potential coupling of metabolic and epigenetic states. Here we identify a network linking …

Through an integration of genomic and proteomic approaches to advance understanding of
long noncoding RNAs, we investigate the function of the telomeric transcript, TERRA. By …

G protein α s (GNAS) mediates receptor-stimulated cAMP signalling, which integrates
diverse environmental cues with intracellular responses. GNAS is mutationally activated in …

Background Sevoflurane anesthesia induces Tau phosphorylation and cognitive impairment
in neonatal but not in adult mice. This study tested the hypothesis that differences in brain …

… and expressing E-cadherin and Fibronectin (E+M+) or fibronectin (M+) alone. Graph shows
the percentage of cells in the E (E+) and M (E+M+, and M+) states (black). Red and yellow …