The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy, and …

Progressive neuronal cell loss in a small subset of brainstem and mesencephalic nuclei and
widespread aggregation of the α-synuclein protein in the form of Lewy bodies and Lewy …

Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-dopa)
therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …

Components of the proteostasis network malfunction in aging, and reduced protein quality
control in neurons has been proposed to promote neurodegeneration. Here, we investigate …

Disrupted homeostasis of the microtubule binding protein tau is a shared feature of a set of
neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early …

Cells rely on surveillance systems such as autophagy to handle protein alterations and
organelle damage. Dysfunctional autophagy, an evolutionarily conserved cellular mechanism for …

In Parkinson’s disease, synucleinopathy is hypothesized to spread from the enteric nervous
system, via the vagus nerve, to the CNS. Here, we compare, in baboon monkeys, the …

… Colocalization was observed after 24 h incubation ((L) and M). Orthogonal projection of
stack image and 3D reconstruction show PLGA-aNP surrounded by LAMP1-GFP signal ((M)and …

… PK was supported by a DFG KI 1992/1-1 postdoctoral fellowship; JM-M is supported by
postdoctoral fellowship 17POST33650088 from the American Heart Association and is a Leducq …

Alzheimer's and Parkinson's diseases are the most prevalent neurodegenerative diseases
that generate important health-related direct and indirect socio-economic costs. They are …