Choices have consequences. Immune cells survey and migrate throughout the body and
sometimes take residence in niche environments with distinct communities of cells, …

Lymphocytes must adapt to a wide array of environmental stressors as part of their normal
development, during which they undergo a dramatic metabolic remodeling process. Research …

Alcohol based cosolvents, such as trifluoroethanol (TFE) have been used for many decades
to denature proteins and to stabilize structures in peptides. Nuclear magnetic resonance …

Background Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in
recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-…

Failure of T cells to protect against cancer is thought to result from lack of antigen recognition,
chronic activation, and/or suppression by other cells. Using a mouse sarcoma model, we …

A novel potassium channel gene has been cloned, characterized, and associated with
cardiac arrhythmia. The gene encodes MinK-related peptide 1 (MiRP1), a small integral …

… , while T M cells maintain fused networks. The fusion protein Opa1 is required for T M , but
not T E cells after infection, and enforcing fusion in T E cells imposes T M cell characteristics …

Generation of CD8 + memory T cells requires metabolic reprogramming that is characterized
by enhanced mitochondrial fatty-acid oxidation (FAO). However, where the fatty acids (FA) …

Excessive production of collagen type I is a major contributor to hepatic fibrosis. Activated (myofibroblastic),
but not quiescent, hepatic stellate cells (lipocytes) have a high level of …

Proprioceptive neuromuscular facilitation (PNF) is a philosophy and a concept of treatment.
The PNF philosophy is timeless, and the concept is a continuous process of growth. This …