All living organisms use numerous signal-transduction systems to sense and respond to their
environments and thereby survive and proliferate in a range of biological niches. Molecular …

Rapamycin is an immunosuppressive natural product that inhibits the proliferation of T-cells
in response to nutrients and growth factors. Rapamycin binds to the peptidyl-prolyl …

… K m for glucose being 0.52 mM), has K m values of 0.06 mM for ATP and 0.6 mM for ITP
with similar V max values [36]. By contrast, rat hexokinase D, despite its much broader sugar …

We report an improved draft nucleotide sequence of the 2.3-gigabase genome of maize, an
important crop plant and model for biological research. Over 32,000 genes were predicted, …

… Biotinylated cRNA was fragmented by incubation at 94C for 35 min in 40 mm Tris acetate
(pH 8.1), 100 mm KOAc, and 30 mm MgOAc. Free unincorporated Biotin nucleotides were …

Groundwater is important for energy and food security, human health and ecosystems. The
time since groundwater was recharged—or groundwater age—can be important for diverse …

Tumour-infiltrating lymphocytes are associated with a survival benefit in several tumour
types and with the response to immunotherapy 1 , 2 , 3 , 4 , 5 , 6 , 7 – 8 . However, the reason …

Improvements in tumor immunotherapies depend on better understanding of the anti-tumor
T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that …

Advection through hyporheic zones (HZ) consisting of heterogeneous channel bend
streambed deposits and their equivalent homogenous medium was investigated using finite …

T cells are important in tumour immunity but a better understanding is needed of the
differentiation of antigen-specific T cells in human cancer 1 , 2 . Here we studied CD8 T cells in …