Ulcerative colitis (UC) is driven by disruptions in host–microbiota homoeostasis, but current
treatments exclusively target host inflammatory pathways. To understand how host–…

Determining the structure and phenotypic context of molecules detected in untargeted
metabolomics experiments remains challenging. Here we present reverse metabolomics as a …

Staphylococcus aureus bacteremia (SaB) causes significant disease in humans, carrying
mortality rates of ∼25%. The ability to rapidly predict SaB patient responses and guide …

Enzyme turnover numbers (k cat s) are essential for a quantitative understanding of cells.
Because k cat s are traditionally measured in low-throughput assays, they can be inconsistent, …

Wnt signalling drives many processes in development, homeostasis and disease; however,
the role and mechanism of individual ligand–receptor (Wnt–Frizzled (Fzd)) interactions in …

Background: Vancomycin is commonly used as a first line therapy for gram positive organisms
such as methicillin resistant Staphylococcus aureus. Vancomycin-induced acute kidney …

Type I interferons (IFNs) exert a broad range of biological effects important in coordinating
immune responses, which have classically been studied in the context of pathogen clearance. …

Background & Aims Hyperbaric oxygen therapy (HBOT) is a promising treatment for
moderate-to-severe ulcerative colitis. However, our current understanding of the host and microbial …

Gulf War illness (GWI) afflicts military personnel who served during the Persian Gulf War and
is notable for cognitive deficits, depression, muscle pain, weakness, intolerance to exercise, …

microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited
microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a …