User profiles for M. Chandrashekhar
Mvs ChandrashekharUniversity of South Carolina Verified email at cec.sc.edu Cited by 5761 |
[HTML][HTML] High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities
The ability to perturb genes in human cells is crucial for elucidating gene function and holds
great potential for finding therapeutic targets for diseases such as cancer. To extend the …
great potential for finding therapeutic targets for diseases such as cancer. To extend the …
Measurement of ultrafast carrier dynamics in epitaxial graphene
Using ultrafast optical pump-probe spectroscopy, we have measured carrier relaxation
times in epitaxial graphene layers grown on SiC wafers. We find two distinct time scales …
times in epitaxial graphene layers grown on SiC wafers. We find two distinct time scales …
Ultrafast optical-pump terahertz-probe spectroscopy of the carrier relaxation and recombination dynamics in epitaxial graphene
The ultrafast relaxation and recombination dynamics of photogenerated electrons and holes
in epitaxial graphene are studied using optical-pump terahertz-probe spectroscopy. The …
in epitaxial graphene are studied using optical-pump terahertz-probe spectroscopy. The …
Measurement of the optical absorption spectra of epitaxial graphene from terahertz to visible
…, J Strait, P George, M Chandrashekhar… - Applied Physics …, 2008 - pubs.aip.org
We present experimental results on the optical absorption spectra of epitaxial graphene
from the visible to the terahertz frequency range. In the terahertz range, the absorption is …
from the visible to the terahertz frequency range. In the terahertz range, the absorption is …
Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens
…, M Aregger, M Chandrashekhar… - G3: Genes …, 2017 - academic.oup.com
… KL holds a Canada Vanier Graduate Scholarship, MA holds a postdoctoral fellowship
award from the Swiss National Science Foundation, and M. Chandrashekhar. holds an Ontario …
award from the Swiss National Science Foundation, and M. Chandrashekhar. holds an Ontario …
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions
…, S Paneesha, P Moss, M Chandrashekhar… - Nature, 2018 - nature.com
The observation that BRCA1- and BRCA2-deficient cells are sensitive to inhibitors of poly(ADP–ribose)
polymerase (PARP) has spurred the development of cancer therapies that use …
polymerase (PARP) has spurred the development of cancer therapies that use …
Ultrafast relaxation dynamics of hot optical phonons in graphene
…, S Shivaraman, VB Shields, M Chandrashekhar… - Applied Physics …, 2010 - pubs.aip.org
… M Γ and M K are the number of phonon modes (per unit area) at the Γ and K ( K ′ ) points,
… The value of M Γ then corresponds to the number of phonon modes that are in the annular …
… The value of M Γ then corresponds to the number of phonon modes that are in the annular …
Carrier recombination and generation rates for intravalley and intervalley phonon scattering in graphene
Electron-hole generation and recombination rates for intravalley and intervalley phonon
scattering in graphene are presented. The transverse and the longitudinal optical phonon …
scattering in graphene are presented. The transverse and the longitudinal optical phonon …
Free-standing epitaxial graphene
…, X Yu, J Alden, L Herman, MVS Chandrashekhar… - Nano …, 2009 - ACS Publications
We report on a method to produce free-standing graphene sheets from epitaxial graphene
on silicon carbide (SiC) substrate. Doubly clamped nanomechanical resonators with lengths …
on silicon carbide (SiC) substrate. Doubly clamped nanomechanical resonators with lengths …
Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
Z Steinhart, Z Pavlovic, M Chandrashekhar, T Hart… - Nature medicine, 2017 - nature.com
Forward genetic screens with CRISPR–Cas9 genome editing enable high-resolution
detection of genetic vulnerabilities in cancer cells. We conducted genome-wide CRISPR–Cas9 …
detection of genetic vulnerabilities in cancer cells. We conducted genome-wide CRISPR–Cas9 …