Systems genetics approaches to understand complex traits
M Civelek, AJ Lusis - Nature Reviews Genetics, 2014 - nature.com
Abstract Systems genetics is an approach to understand the flow of biological information
that underlies complex traits. It uses a range of experimental and statistical methods to …
that underlies complex traits. It uses a range of experimental and statistical methods to …
The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo
… Civelek et al. rediscovered the prominence of ER stress and the UPR in vivo during
analyses of transcription profiles in a multi-site study in normal adult swine. Endothelium in the …
analyses of transcription profiles in a multi-site study in normal adult swine. Endothelium in the …
[HTML][HTML] The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits
The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized
inbred strains of mice that can be used to analyze the genetic and environmental …
inbred strains of mice that can be used to analyze the genetic and environmental …
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
Integrative approaches for large-scale transcriptome-wide association studies
Many genetic variants influence complex traits by modulating gene expression, thus altering
the abundance of one or multiple proteins. Here we introduce a powerful strategy that …
the abundance of one or multiple proteins. Here we introduce a powerful strategy that …
[PDF][PDF] Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice
… (x,M,K,N), where x is the total number of genes in genome, M is the total number of genes
identified in mouse and humans, K s the number of genes identified in obesity and BMI human …
identified in mouse and humans, K s the number of genes identified in obesity and BMI human …
[PDF][PDF] Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism
Venous thromboembolism (VTE), the third leading cause of cardiovascular mortality, is a
complex thrombotic disorder with environmental and genetic determinants. Although several …
complex thrombotic disorder with environmental and genetic determinants. Although several …
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
Atherosclerosis is the disease process that underlies heart attack and stroke 1 . Advanced
lesions at risk of rupture are characterized by the pathological accumulation of diseased …
lesions at risk of rupture are characterized by the pathological accumulation of diseased …
MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro
…, C Shi, E Manduchi, M Civelek… - Proceedings of the …, 2010 - National Acad Sciences
A chronic proinflammatory state precedes pathological change in arterial endothelial cells
located within regions of susceptibility to atherosclerosis. The potential contributions of …
located within regions of susceptibility to atherosclerosis. The potential contributions of …
Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men
A Stančáková, M Civelek, NK Saleem, P Soininen… - Diabetes, 2012 - Am Diabetes Assoc
<p>We investigated the association of glycemia and 43 genetic risk variants for hyperglycemia/type
2 diabetes with amino acid levels in the population-based Metabolic Syndrome in …
2 diabetes with amino acid levels in the population-based Metabolic Syndrome in …