Antioxidants in the diet and supplements are widely used to protect against cancer, but
clinical trials with antioxidants do not support this concept. Some trials show that antioxidants …

Recent clinical trials have demonstrated a clear survival advantage in advanced head and
neck squamous cell carcinoma (HNSCC) patients treated with immune checkpoint blockade. …

Salivary gland cancers comprise a small subset of human malignancies, and are classified
into multiple subtypes that exhibit diverse histology, molecular biology and clinical …

Anti-tumor immunity is driven by self versus non-self discrimination. Many immunotherapeutic
approaches to cancer have taken advantage of tumor neoantigens derived from somatic …

Purpose: Salivary duct carcinoma (SDC) is an aggressive salivary malignancy, which is
resistant to chemotherapy and has high mortality rates. We investigated the molecular …

… Since most R/M cases were sequenced at higher depth with targeted NGS panels, we
assessed the possibility that those mutations enriched in R/M cases might have been mutations …

Abstract Analysis of circulating cell-free tumor DNA (ctDNA) has shown promising results
within several clinical applications, including cancer detection, mutation profiling, treatment …

RAS and RHO proteins, which contribute to tumorigenesis and metastasis, undergo
posttranslational modification with an isoprenyl lipid by protein farnesyltransferase (FTase) or …

Purpose: Salivary gland carcinomas (SGC) are rare, aggressive cancers with high rates of
recurrence and distant metastasis. These factors, and a lack of active systemic therapies, …

Protein geranylgeranyltransferase type I (GGTase-I) is responsible for the posttranslational
lipidation of CAAX proteins such as RHOA, RAC1, and cell division cycle 42 (CDC42). …