The opposing activities of 53BP1 and BRCA1 influence pathway choice in DNA double-strand-break
repair. How BRCA1 counteracts the inhibitory effect of 53BP1 on DNA resection …

The integrity of genomes is constantly threatened by problems encountered by the replication
fork. BRCA1, BRCA2 and a subset of Fanconi anaemia proteins protect stalled replication …

Diacylglycerol kinase (DGK) α converts diacylglycerol to phosphatidic acid. This lipid kinase
sustains survival, migration and invasion of tumor cells, with no effect over untransformed …

Accurate chromosomal DNA replication is essential to maintain genomic stability. Genetic
evidence suggests that certain repetitive sequences impair replication, yet the underlying …

SUMOylation (small ubiquitin-like modifier) in the DNA double-strand break (DSB) response
regulates recruitment, activity, and clearance of repair factors. However, our understanding …

The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through
homologous recombinational DNA repair and by protecting stalled replication forks from …

BRCA1, BRCA2 and a subset of Fanconi’s Anaemia proteins act to promote RAD51-mediated
protection of newly synthesised DNA at stalled replication forks from degradation by …

Lesions in DNA can lead to accumulation of mutations that may cause cancer progression
and disease. DNA repair is essential to overcome these lesions maintaining genomic integrity …

In April of 2000, seventeen-year-old Víctor Hugo Daza was shot in the face while walking
home from work. He was not a revolutionary, nor was he a militant youth protestor, but he could …

Ehlers–Danlos syndrome (EDS) describes a group of clinical entities in which the connective
tissue, primarily that of the skin, joint and vessels, is abnormal, although the resulting …