Atherosclerosis, the main pathophysiological condition leading to cardiovascular disease (CVD),
is now considered to be a chronic inflammatory condition. Statins are the most widely …

Background— Adiponectin is an adipokine with potentially important roles in human cardiovascular
disease states. We studied the role of adiponectin in the cross-talk between adipose …

Background— Treatment with statins improves clinical outcome, but the exact mechanisms
of pleiotropic statin effects on vascular function in human atherosclerosis remain unclear. We …

Introduction No uniform consensus in the UK or Europe exists, for glycaemic management of
patients with Diabetes or pre-diabetes undergoing cardiac surgery. Objective [i] Determine …

Background—Statins improve clinical outcome of patients with atherosclerosis, but their
perioperative role in patients undergoing coronary artery bypass grafting (CABG) is unclear. We …

Objectives : The purpose of this study was to evaluate the role of the myocardial redox state
in the development of in-hospital complications after cardiac surgery and the effect of statins …

Objective— To explore the role of systemic inflammation in the regulation of adiponectin
levels in patients with ischemic heart disease. Approach and Results— In a cross-sectional …

Objective: The therapeutic mechanism of electroconvulsive therapy (ECT) is unknown.
Animal research supports a neurotrophic effect of ECT. To investigate a neurotrophic effect in …

We explored the role of asymmetrical dimethylarginine (ADMA) as a cause of endothelial
dysfunction induced by systemic inflammation. In vitro data suggest that ADMA bioavailability is …

Background— The endothelial nitric oxide synthase cofactor tetrahydrobiopterin (BH4) is
essential for maintenance of enzymatic function. We hypothesized that induction of BH4 …