User profiles for M. Diard

Médéric RJ Diard

SNSF Assistant Professor, Basel University Biozentrum
Verified email at unibas.ch
Cited by 4606

Evolutionary causes and consequences of bacterial antibiotic persistence

E Bakkeren, M Diard, WD Hardt - Nature Reviews Microbiology, 2020 - nature.com
… Additionally, it was recently shown that a host factor, SLC11a1, which restricts systemic
growth of pathogens such as M. tuberculosis and S. Typhimurium by depleting local Mg 2+ …

The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen's virulence factors, and the host's mucosal immune …

P Kaiser, M Diard, B Stecher… - Immunological reviews, 2012 - Wiley Online Library
… enterica serovar Typhi: bacteria invade the mucosa via M-cells, colonize Peyer′s patches
… We are grateful to the members of the Hardt lab for in depth discussions and to M. Rohde, P. …

Evolution of bacterial virulence

M Diard, WD Hardt - FEMS microbiology reviews, 2017 - academic.oup.com
Bacterial virulence is highly dynamic and context-dependent. For this reason, it is challenging
to predict how molecular changes affect the growth of a pathogen in a host and its spread …

[HTML][HTML] Organised Genome Dynamics in the Escherichia coli Species Results in Highly Diverse Adaptive Paths

…, O Clermont, S Cruveiller, A Danchin, M Diard… - PLoS …, 2009 - journals.plos.org
The Escherichia coli species represents one of the best-studied model organisms, but also
encompasses a variety of commensal and pathogenic strains that diversify by high rates of …

[PDF][PDF] Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa

…, AA Müller, B Felmy, T Dolowschiak, M Diard… - Cell host & …, 2014 - cell.com
The gut mucosal epithelium separates the host from the microbiota, but enteropathogens such
as Salmonella Typhimurium (S.Tm) can invade and breach this barrier. Defenses against …

High-avidity IgA protects the intestine by enchaining growing bacteria

K Moor, M Diard, ME Sellin, B Felmy, SY Wotzka… - Nature, 2017 - nature.com
Vaccine-induced high-avidity IgA can protect against bacterial enteropathogens by directly
neutralizing virulence factors or by poorly defined mechanisms that physically impede …

Stabilization of cooperative virulence by the expression of an avirulent phenotype

M Diard, V Garcia, L Maier, MNP Remus-Emsermann… - Nature, 2013 - nature.com
… For infection, bacteria were grown in 0.3 M NaCl LB medium supplemented with the appropriate
antibiotic for 12 h at 37 C, and subcultured for 4 h in the same medium without antibiotic …

[HTML][HTML] Bistable Expression of Virulence Genes in Salmonella Leads to the Formation of an Antibiotic-Tolerant Subpopulation

…, IA Vizcarra, R Peña-Miller, N Stocker, M Diard… - PLoS …, 2014 - journals.plos.org
M Diard was supported in part by the Fondation pour la Recherche Medicale. The funders
had no role in study design, data collection and analysis, decision to publish, or preparation of …

Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut

…, ME Sellin, S Bonhoeffer, RR Regoes, M Diard… - Nature, 2019 - nature.com
The emergence of antibiotic-resistant bacteria through mutations or the acquisition of
genetic material such as resistance plasmids represents a major public health issue 1 , 2 . …

Inflammation boosts bacteriophage transfer between Salmonella spp.

M Diard, E Bakkeren, JK Cornuault, K Moor… - Science, 2017 - science.org
Bacteriophage transfer (lysogenic conversion) promotes bacterial virulence evolution. There
is limited understanding of the factors that determine lysogenic conversion dynamics within …