Narcolepsy is strongly associated with the T-cell receptor alpha locus

…, D Kemlink, M Einen, J Chen, SL Musone, M Akana… - Nature …, 2009 - nature.com
Narcolepsy with cataplexy, characterized by sleepiness and rapid onset into REM sleep, affects
1 in 2,000 individuals 1 , 2 . Narcolepsy was first shown to be tightly associated with HLA-…

Common variants in P2RY11 are associated with narcolepsy

…, KP Strohl, WT Longstreth Jr, M Kvale, M Dobrovolna… - Nature …, 2011 - nature.com
Growing evidence supports the hypothesis that narcolepsy with cataplexy is an autoimmune
disease. We here report genome-wide association analyses for narcolepsy with replication …

[HTML][HTML] ImmunoChip study implicates antigen presentation to T cells in narcolepsy

…, L Lin, BR Kornum, EE Kenny, G Trynka, M Einen… - PLoS …, 2013 - journals.plos.org
… Collection of European samples was partly supported through EU-NN and UCB Pharma
grants to M Tafti. French sample collection was funded by PHRC 07-0138 Narcobank grant, by …

Post-H1N1 narcolepsy-cataplexy

…, V Cochen, A Desautels, M Einen, L Lin, M Kawashima… - Sleep, 2010 - academic.oup.com
SLEEP, Vol. 33, No. 11, 2010 1429 Letter to the Editor—Dauvilliers et al lay between onset
and diagnosis is often long, 1, 13 more cases are likely to be identified in the future. How …

Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy

…, S Nishino, F Han, MH Silber, T Rico, M Einen… - Sleep, 2012 - academic.oup.com
Study Objectives: To compare clinical, electrophysiologic, and biologic data in narcolepsy
without cataplexy with low (≤ 110 pg/ml), intermediate (110–200 pg/ml), and normal (> 200 pg…

Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children

A Aran, M Einen, L Lin, G Plazzi, S Nishino, E Mignot - Sleep, 2010 - academic.oup.com
Study Objective: To report on symptoms and therapies used in childhood narcolepsy-cataplexy.
Design, Patients, and Setting: Retrospective series of 51 children who completed the …

[HTML][HTML] Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

…, T Olsson, I Kockum, M Partinen, M Perola… - Nature …, 2023 - nature.com
Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors
include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here…

[PDF][PDF] HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy

…, SJ Mack, M Mindrinos, M Fernandez-Vina… - The American Journal of …, 2015 - cell.com
Type 1 narcolepsy, a disorder caused by a lack of hypocretin (orexin), is so strongly
associated with human leukocyte antigen (HLA) class II HLA-DQA1 ∗ 01:02-DQB1 ∗ 06:02 (DQ0602…

Plasma intestinal fatty acid binding protein (I-FABP) concentrations increase following intestinal ischemia in pigs

TA Niewold, M Meinen, J Van der Meulen - Research in veterinary science, 2004 - Elsevier
Intestinal fatty acid binding protein (I-FABP) is an intracellular epithelial protein in the intestinal
mucosa of many animals. I-FABP appears in the circulation following epithelial damage, …

CD4+ T Cell Autoimmunity to Hypocretin/Orexin and Cross-Reactivity to a 2009 H1N1 Influenza A Epitope in Narcolepsy

…, W Jiang, L Lin, T Hou, C Macaubas, M Einen… - Science translational …, 2013 - science.org
Narcolepsy, a disorder strongly associated with human leukocyte antigen (HLA)–DQA1*01:02/DQB1*06:02
(DQ0602), is characterized by excessive daytime sleepiness, cataplexy, and …