From bacteria to humans, cells secrete a large variety of membrane-bound extracellular
vesicles. Only relatively recently has it however started to become clear that the exovesicular …

… In 85% of embryos (36/42) this induces sef expression compared with the wild type (m). o,
sef is induced in 85% (46/54) of embryos following local injection of 90 pg of ca-FGFR1(ca-R1…

… We thank M. Hammerschmidt for communicating data prior to publication; V. Heyer and T. …
We are grateful to M. Halpern for gamma-irradiated fish, M. Fishman and E. Knapik for SSLP …

Endocytosis has a crucial role during Notch signalling after the asymmetric division of fly
sensory organ precursors (SOPs): directional signalling is mediated by differential endocytosis …

Delta/Notch signalling is of major importance for embryonic development and adult life.
While endocytosis is often viewed as a way to down‐regulate biological signals, ligand and …

… The staining reaction was arrested by three 5 minute washes in 0.1 M glycine buffer (pH
2.2), 0.1% Tween20. After overnight incubation with a 1:5000 dilution of anti-fluorescein …

In looking for novel factors involved in the regulation of the fibroblast growth factor (FGF)
signaling pathway, we have isolated a zebrafish sprouty4 gene, based on its extensive …

Signals released from Spemann’s organizer, together with ventralizing factors such as BMPs,
are necessary to pattern the dorsoventral axis of the vertebrate embryo. We report that a …

… F-actin staining is used to outline the cell cortex (m, o). Magnified views of dorsal-posterior
cells are shown in the top-right corner. f–o, The dorsal–ventral boundary is marked with a …

… diluted in 0.2% Phenol Red and 0.1 M KCl, using an Eppendorf 5426 microinjector. … (M–O)
Expression of the notochordal marker floating-head (flh) at 75% epiboly. (A, D, G, J, …