The gut microbiota is associated with immune cell dynamics in humans

…, S Morjaria, M Fenelus, MS Pessin, NJ Chao, M Lew… - Nature, 2020 - nature.com
The gut microbiota influences development 1 , 2 – 3 and homeostasis 4 , 5 , 6 – 7 of the
mammalian immune system, and is associated with human inflammatory 8 and immune …

Comparative risk of pulmonary adverse events with transfusion of pathogen reduced and conventional platelet components

…, M Sehl, AK Nooka, L Uhl, P Spinella, M Fenelus… - …, 2022 - Wiley Online Library
Background Platelet transfusion carries risk of transfusion‐transmitted infection (TTI). Pathogen
reduction of platelet components (PRPC) is designed to reduce TTI. Pulmonary adverse …

Anti-cancer peptides from ras-p21 and p53 proteins

MR Pincus, M Fenelus… - Current …, 2011 - ingentaconnect.com
We have employed computer-based molecular modeling approaches to design peptides from
the ras-p21 and p53 proteins that either induce tumor cell reversion to the untransformed …

Accuracy and risk of malignancy for diagnostic categories in urine cytology at a large tertiary institution

…, M Fenelus, R Brenkert, M Klein… - Cancer …, 2015 - Wiley Online Library
BACKGROUND At a high‐volume center, it became necessary to provide benchmarks for
the accuracy and risk of malignancy per urine cytology diagnostic category. The additive …

Rethinking the need for a platelet transfusion threshold of 50 × 109/L for lumbar puncture in cancer patients

…, AW Zhang, SC Martin, A Bhatia, M Fenelus… - …, 2020 - Wiley Online Library
Background Lumbar puncture (LP) is a frequently performed diagnostic and therapeutic
procedure in oncology patients. Transfusing to a minimum preprocedural platelet threshold of 50 …

The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM …

K Davitt, BD Babcock, M Fenelus… - Annals of Clinical & …, 2014 - Assoc Clin Scientists
Goals We have developed the anti-cancer peptide, PNC-27, which is a membrane-active
peptide that binds to the HDM-2 protein expressed in the cancer cell membranes of solid tissue …

Acute Pulmonary Injury in Hematology Patients Supported with Pathogen Reduced and Conventional Platelet Components

…, AK Nooka, L Uhl, PC Spinella, M Fenelus… - Blood …, 2024 - ashpublications.org
Patients treated with anti-neoplastic therapy often develop thrombocytopenia requiring
platelet transfusion which has potential to exacerbate pulmonary injury. This study tested the …

[HTML][HTML] Tumor suppressor CD99 is downregulated in plasma cell neoplasms lacking CCND1 translocation and distinguishes neoplastic from normal plasma cells and …

Q Gao, V Yellapantula, M Fenelus, J Pichardo, L Wang… - Modern Pathology, 2018 - Elsevier
CD99(MIC2) is a widely expressed cell surface glycoprotein and functions as a tumor suppressor
involved in downregulation of SRC family of tyrosine kinase. CD99 expression is tightly …

The gut microbiota influences how circulating immune cells in humans change from one day to the next

…, S Morjaria, M Fenelus, MS Pessin, NJ Chao, M Lew… - BioRxiv, 2019 - biorxiv.org
The gut microbiota influences the development and homeostasis of the mammalian immune
system 1 – 3 , can alter immune cell compositions in mice 4 – 7 , and is associated with …

[HTML][HTML] Laboratory evaluation of folate deficiency among inpatients with cancer

…, S Lobaugh, S Devlin, M Fenelus… - … journal of laboratory …, 2021 - ncbi.nlm.nih.gov
Anemia in hospitalized patients is common, with multiple potential contributing factors.
Evaluation of anemia in patients with cancer is particularly challenging given the potential …