… in a larger siRNA screen, including RhoA, Gα 12 and Gα 13 , also resulted in reduced
migration and low axial ratio in a PKT assay (M. Fokkelman and VM Rogkoti, data unpublished). …

Ttriple-negative breast cancer (TNBC) is an aggressive and highly metastatic breast cancer
subtype. Enhanced TNBC cell motility is a prerequisite of TNBC cell dissemination. Here, we …

… m a x − 3 S D m a x n ) − ( A V G m i n + 3 S D m i n n ) A V G m a x − A V G m i n ( eq 1 ) 17 …
Fokkelman was supported by the EU-FP7—Systems Microscopy NoE (grant no. 258068). The …

Cancer cells migrate from the primary tumour into surrounding tissue in order to form metastasis.
Cell migration is a highly complex process, which requires continuous remodelling and …

… A positive coefficient (risk factor) for M (or P) indicates that the higher value of M (or P), the
lower the patient survival. (a) Coefficients of M, P when used to predict survival individually …

Polycystic kidney disease (PKD) is a prevalent genetic disorder, characterized by the
formation of kidney cysts that progressively lead to kidney failure. The currently available drug …

Cis-diamminedichloroplatinum(II) (cisplatin)–induced renal proximal tubular apoptosis is
known to be preceded by actin cytoskeleton reorganization, in conjunction with disruption of cell…

Cell migration is a highly complex and dynamic biological process, essential in several
physiological phenomena and pathologies including cancer dissemination and metastasis …

Introduction The pharmaceutical industry has mostly relied on 2D cancer cell lines and 3D
spheroids for in vitro testing, but poor correlation of pre-clinical and clinical outcomes has …

Metastasis is the major cause of death in cancer patients and migration of cancer cells from
the primary tumor to distant sites is the prerequisite of metastasis formation. Here we applied …